S
Sara Ahrabi
Researcher at University of Oxford
Publications - 4
Citations - 456
Sara Ahrabi is an academic researcher from University of Oxford. The author has contributed to research in topics: Homologous recombination & Cas9. The author has an hindex of 3, co-authored 3 publications receiving 372 citations.
Papers
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Journal ArticleDOI
SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability
Sophia X. Pfister,Sara Ahrabi,Lykourgos-Panagiotis Zalmas,Sovan Sarkar,François Aymard,François Aymard,Csanád Z. Bachrati,Thomas Helleday,Gaëlle Legube,Gaëlle Legube,Nicholas B. La Thangue,Andrew C.G. Porter,Timothy C. Humphrey +12 more
TL;DR: A role for H3K36 trimethylation in homologous recombination (HR) repair in human cells is defined and it is proposed that error-free HR repair within H3k36me3-decorated transcriptionally active genomic regions promotes cell homeostasis.
Journal ArticleDOI
A role for human homologous recombination factors in suppressing microhomology-mediated end joining.
Sara Ahrabi,Sovan Sarkar,Sophia X. Pfister,Giacomo Pirovano,Geoff S. Higgins,Andrew C.G. Porter,Timothy C. Humphrey +6 more
TL;DR: A role for HR genes in suppressing MMEJ in human cells is described and findings indicate that HR factors suppress mutagenic MMEj following DSB resection.
Journal ArticleDOI
Use of the HPRT gene to study nuclease-induced DNA double-strand break repair
Polly Gravells,Sara Ahrabi,Rajani K. Vangala,Kazunori Tomita,James T. Brash,Lena A. Brustle,Christopher Chung,Julia M. Hong,Aikaterini Kaloudi,Timothy C. Humphrey,Andrew C.G. Porter +10 more
TL;DR: Using a single endogenous reporter gene, the X-chromosomal disease gene encoding hypoxanthine phosphoribosyltransferase (HPRT), the relative utilization of three DSBR pathways following cleavage by I-SceI or CRISPR/Cas9 nucleases is monitored.
Journal ArticleDOI
Optimizing CRISPR/Cas9 Editing of Repetitive Single Nucleotide Variants
Inga Usher,Lorena Ligammari,Sara Ahrabi,Emily Hepburn,Calum Connolly,Gareth L. Bond,Adrienne M. Flanagan,Lucia Cottone +7 more
TL;DR: It is found that in silico predictions of guide RNA efficiency correlated poorly withactivity in cells, and the steps in this process in a flowchart for those embarking on genome editing using any system and incorporate validated HDR-boosting modifications for those using CRISPR/Cas9.