L
Lykourgos-Panagiotis Zalmas
Researcher at Wellcome Trust Sanger Institute
Publications - 12
Citations - 1104
Lykourgos-Panagiotis Zalmas is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: DNA damage & Chromosome instability. The author has an hindex of 8, co-authored 11 publications receiving 807 citations. Previous affiliations of Lykourgos-Panagiotis Zalmas include University of Oxford & Francis Crick Institute.
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Journal ArticleDOI
SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability
Sophia X. Pfister,Sara Ahrabi,Lykourgos-Panagiotis Zalmas,Sovan Sarkar,François Aymard,François Aymard,Csanád Z. Bachrati,Thomas Helleday,Gaëlle Legube,Gaëlle Legube,Nicholas B. La Thangue,Andrew C.G. Porter,Timothy C. Humphrey +12 more
TL;DR: A role for H3K36 trimethylation in homologous recombination (HR) repair in human cells is defined and it is proposed that error-free HR repair within H3k36me3-decorated transcriptionally active genomic regions promotes cell homeostasis.
Journal ArticleDOI
Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.
Sophia X. Pfister,Enni Markkanen,Yanyan Jiang,Sovan Sarkar,Mick Woodcock,Giulia Orlando,Ioanna Mavrommati,Chen-Chun Pai,Lykourgos-Panagiotis Zalmas,Neele Drobnitzky,Grigory L. Dianov,Clare Verrill,Valentine M. Macaulay,Valentine M. Macaulay,Songmin Ying,Nicholas B. La Thangue,Vincenzo D'Angiolella,Anderson J. Ryan,Timothy C. Humphrey +18 more
TL;DR: A synthetic lethal interaction in which H3K36me3-deficient cancers are acutely sensitive to WEE1 inhibition is identified, and it is shown that RRM2, a ribonucleotide reductase subunit, is the target of this syntheticlethal interaction.
Journal ArticleDOI
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer
Nnennaya Kanu,Maria Antonietta Cerone,Gerald Goh,Lykourgos-Panagiotis Zalmas,Jirina Bartkova,Michelle Dietzen,Nicholas McGranahan,Rebecca Rogers,Emily K. Law,Irina Gromova,Maik Kschischo,Michael I. Walton,Olivia W. Rossanese,Jiri Bartek,Reuben S. Harris,Subramanian Venkatesan,Charles Swanton +16 more
TL;DR: In this paper, the authors identify a molecular basis for APOBEC3 expression and activation, and show that HER2 amplification and PTEN loss promote DNA replication stress and increase DNA replication damage.
Journal ArticleDOI
Arginine Methylation-Dependent Reader-Writer Interplay Governs Growth Control by E2F-1
Shunsheng Zheng,Shunsheng Zheng,Jutta Moehlenbrink,Yi Chien Lu,Lykourgos-Panagiotis Zalmas,Cari A. Sagum,Simon M. Carr,Joanna F. McGouran,Leila T. Alexander,Oleg Fedorov,Shonagh Munro,Benedikt M. Kessler,Mark T. Bedford,Qiang Yu,Nicholas B. La Thangue +14 more
TL;DR: The results define an exquisite level of precision in the reader-writer interplay that governs the biological outcome of E2F-1 activity.
Journal ArticleDOI
The PROTACtable genome
Melanie Schneider,Chris J Radoux,Andrew Hercules,David Ochoa,Ian Dunham,Lykourgos-Panagiotis Zalmas,Gerhard Hessler,Sven Ruf,Veerabahu Shanmugasundaram,Michael M. Hann,Pamela Thomas,Markus A. Queisser,Andrew B. Benowitz,Kris Brown,Andrew R. Leach +14 more
TL;DR: In this article, the tractability of PROTAC-targeting chimeras is assessed using a series of criteria based on data and information from a diverse range of relevant publicly available resources.