S
Sophia X. Pfister
Researcher at University of Oxford
Publications - 13
Citations - 994
Sophia X. Pfister is an academic researcher from University of Oxford. The author has contributed to research in topics: Cyclin-dependent kinase & DNA repair. The author has an hindex of 7, co-authored 13 publications receiving 796 citations. Previous affiliations of Sophia X. Pfister include University of California, San Francisco & Siemens.
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Journal ArticleDOI
SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability
Sophia X. Pfister,Sara Ahrabi,Lykourgos-Panagiotis Zalmas,Sovan Sarkar,François Aymard,François Aymard,Csanád Z. Bachrati,Thomas Helleday,Gaëlle Legube,Gaëlle Legube,Nicholas B. La Thangue,Andrew C.G. Porter,Timothy C. Humphrey +12 more
TL;DR: A role for H3K36 trimethylation in homologous recombination (HR) repair in human cells is defined and it is proposed that error-free HR repair within H3k36me3-decorated transcriptionally active genomic regions promotes cell homeostasis.
Journal ArticleDOI
Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.
Sophia X. Pfister,Enni Markkanen,Yanyan Jiang,Sovan Sarkar,Mick Woodcock,Giulia Orlando,Ioanna Mavrommati,Chen-Chun Pai,Lykourgos-Panagiotis Zalmas,Neele Drobnitzky,Grigory L. Dianov,Clare Verrill,Valentine M. Macaulay,Valentine M. Macaulay,Songmin Ying,Nicholas B. La Thangue,Vincenzo D'Angiolella,Anderson J. Ryan,Timothy C. Humphrey +18 more
TL;DR: A synthetic lethal interaction in which H3K36me3-deficient cancers are acutely sensitive to WEE1 inhibition is identified, and it is shown that RRM2, a ribonucleotide reductase subunit, is the target of this syntheticlethal interaction.
Journal ArticleDOI
Marked for death: targeting epigenetic changes in cancer.
Sophia X. Pfister,Alan Ashworth +1 more
TL;DR: Recent advances in epigenetic drug discovery and development are presented, and possible future avenues of investigation are suggested to drive progress in this area.
Journal ArticleDOI
A role for human homologous recombination factors in suppressing microhomology-mediated end joining.
Sara Ahrabi,Sovan Sarkar,Sophia X. Pfister,Giacomo Pirovano,Geoff S. Higgins,Andrew C.G. Porter,Timothy C. Humphrey +6 more
TL;DR: A role for HR genes in suppressing MMEJ in human cells is described and findings indicate that HR factors suppress mutagenic MMEj following DSB resection.
Journal ArticleDOI
SET-ting the stage for DNA repair
TL;DR: Five new reports shed light on the contributions of chromatin to this process by uncovering roles for histone H3 Lys36 methylation, a post-translational modification previously linked to transcription elongation, in the control of DNA-damage signaling and double strand break repair.