S
Sara Castiglia
Researcher at Boston Children's Hospital
Publications - 21
Citations - 896
Sara Castiglia is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Mesenchymal stem cell & Reperfusion injury. The author has an hindex of 13, co-authored 20 publications receiving 801 citations. Previous affiliations of Sara Castiglia include University of Turin.
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Journal ArticleDOI
Generation of endogenous hydrogen sulfide by cystathionine γ -lyase limits renal ischemia/reperfusion injury and dysfunction
Pinpat Tripatara,Pinpat Tripatara,Nimesh S. A. Patel,Massimo Collino,Margherita Gallicchio,Julius Kieswich,Sara Castiglia,Elisa Benetti,Keith N. Stewart,Paul A.J. Brown,Mohammed M. Yaqoob,Roberto Fantozzi,Christoph Thiemermann +12 more
TL;DR: The findings suggest that the synthesis of endogenous hydrogen sulfide by CSE is essential to protect the kidney against ischemia/reperfusion injury and dysfunction and aids in the recovery of renal function following ischemIA/rePerfusion.
Journal ArticleDOI
Pioglitazone improves lipid and insulin levels in overweight rats on a high cholesterol and fructose diet by decreasing hepatic inflammation.
Massimo Collino,Manuela Aragno,Sara Castiglia,Gianluca Miglio,C. Tomasinelli,Giuseppe Boccuzzi,Christoph Thiemermann,Roberto Fantozzi +7 more
TL;DR: This study investigated the hepatic signalling pathway activated by PPARγ activation in a non‐genetic insulin‐resistant animal model to investigate the involvement of suppressor of cytokine signalling (SOCS‐3) in the pathogenesis of insulin resistance.
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Insulin Reduces Cerebral Ischemia/Reperfusion Injury in the Hippocampus of Diabetic Rats: A Role for Glycogen Synthase Kinase-3β
Massimo Collino,Manuela Aragno,Sara Castiglia,C. Tomasinelli,Christoph Thiemermann,Giuseppe Boccuzzi,Roberto Fantozzi +6 more
TL;DR: It is proposed that the inhibitory effect on the activity of GSK-3β contributes to the protective effect of insulin independently of any effects on blood glucose.
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Protective role of peroxisome proliferator-activated receptor-β/δ in septic shock.
Amar Kapoor,Yasunori Shintani,Massimo Collino,Marcin F. Osuchowski,Daniel Busch,Nimesh S. A. Patel,Bruno Sepodes,Sara Castiglia,Roberto Fantozzi,David Bishop-Bailey,Helder Mota-Filipe,Muhammad M. Yaqoob,Ken Suzuki,Soheyl Bahrami,Béatrice Desvergne,Jane Mitchell,Christoph Thiemermann +16 more
TL;DR: In this paper, the role of PPAR-β/δ in sepsis was investigated in murine models of LPS-induced organ injury and dysfunction and cecal ligation and puncture (CLP) induced polymicrobial septis.
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Multipotent Mesenchymal Stromal Stem Cell Expansion by Plating Whole Bone Marrow at a Low Cellular Density: A More Advantageous Method for Clinical Use
Katia Mareschi,Katia Mareschi,Deborah Rustichelli,Roberto Calabrese,Monica Gunetti,Fiorella Sanavio,Sara Castiglia,Alessandra Risso,Ivana Ferrero,Ivana Ferrero,Corrado Tarella,Franca Fagioli +11 more
TL;DR: Plating whole bone marrow at a low cellular density may represent a good procedure for MSC expansion for clinical use and no differences were observed in terms of gross morphology, differentiation potential or immunophenotype.