Sara R. Holman

TL;DR: It is shown that a thyroid hormone surge activates the IGF-1/IGF-1-R/Akt pathway on postnatal day 15 and initiates a brief but intense proliferative burst of predominantly binuclear cardiomyocytes, suggesting persistence of carduomyocyte proliferative capacity beyond the perinatal period.

TL;DR: Findings are consistent with the notion that intracellularly, under physiological conditions, TG2 is maintained largely as a latent enzyme, its calcium-activated cross-linking activity being suppressed allosterically by guanine nucleotide binding.

TL;DR: The conservation of Trp-241 in all eukaryotic transglutaminases and the finding that W241Q-TG2 had a much lower kcat than wild-type enzyme suggest evolutionary specialization in the use of the indole group.

TL;DR: The data indicate that glucose homeostasis in mice is TG2 independent, and question a link between TG2 and diabetes.

TL;DR: Pre-existing cardiac hypertrophy lowers wall stress in dn-c-kit-Tg hearts, limits infarct expansion and prevents death from myocardial rupture, relative to NTL mice.