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Sarah A. McDermid
Researcher at New York Medical College
Publications - 3
Citations - 597
Sarah A. McDermid is an academic researcher from New York Medical College. The author has contributed to research in topics: Human serum albumin & Gadolinium. The author has an hindex of 3, co-authored 3 publications receiving 581 citations. Previous affiliations of Sarah A. McDermid include Pennsylvania State University.
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Journal ArticleDOI
The interaction of MS-325 with human serum albumin and its effect on proton relaxation rates.
Peter Caravan,Normand J. Cloutier,Matthew T. Greenfield,Sarah A. McDermid,Stephen U. Dunham,Jeff W.M. Bulte,John C. Amedio,Richard J. Looby,Ronald M. Supkowski,William DeW. Horrocks,Thomas J. McMurry,Randall B. Lauffer +11 more
TL;DR: The results suggest that MS-325 binds primarily to site II on HSA, and the relaxivity of MS- 325 when bound to HSA is shown to be site dependent.
Journal ArticleDOI
Albumin binding, relaxivity, and water exchange kinetics of the diastereoisomers of MS-325, a gadolinium(III)-based magnetic resonance angiography contrast agent.
Peter Caravan,Giacomo Parigi,Jaclyn M. Chasse,Normand J. Cloutier,Jeffrey J. Ellison,Randall B. Lauffer,Claudio Luchinat,Sarah A. McDermid,Marga Spiller,Thomas J. Mcmurry +9 more
TL;DR: The amphiphilic gadolinium complex MS-325 binds to human serum albumin (HSA) in plasma resulting in an extended plasma half-life, retention of the agent within the blood compartment, and an increased relaxation rate of water protons in plasma.
Journal ArticleDOI
When are two waters worse than one? Doubling the hydration number of a Gd-DTPA derivative decreases relaxivity.
Peter Caravan,John C. Amedio,Stephen U. Dunham,Matthew T. Greenfield,Normand J. Cloutier,Sarah A. McDermid,Marga Spiller,Stephan G. Zech,Richard J. Looby,Arnold M. Raitsimring,Thomas J. McMurry,Randall B. Lauffer +11 more
TL;DR: Despite having two exchangeable water molecules, slow water exchange limits the potential efficacy of Gd-L1 as an MRI contrast agent.