S
Sarah E. Lewis
Researcher at Washington University in St. Louis
Publications - 3
Citations - 280
Sarah E. Lewis is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Membrane topology & Transport protein. The author has an hindex of 3, co-authored 3 publications receiving 265 citations.
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Journal ArticleDOI
FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation
Ilaria Meloni,Maddalena Muscettola,Martine Raynaud,Ilaria Longo,Mirella Bruttini,Marie Pierre Moizard,Marie Gomot,Jamel Chelly,Vincent des Portes,Jean Pierre Fryns,Hans-Hilger Ropers,Barbara Magi,Cristina Bellan,Nila Volpi,Helger G. Yntema,Sarah E. Lewis,Jean E. Schaffer,Alessandra Renieri +17 more
TL;DR: FACL4 is the first gene shown to be involved in nonspecific mental retardation and fatty-acid metabolism, and Analysis of enzymatic activity in lymphoblastoid cell lines from affected individuals of both families revealed low levels compared with normal cells, indicating that both mutations are null mutations.
Journal ArticleDOI
Membrane Topology of the Murine Fatty Acid Transport Protein 1
TL;DR: This study provides the first experimental evidence for topology of a member of the family of plasma membrane fatty acid transport proteins as a polytopic membrane protein with at least one transmembrane and multiple membrane-associated domains.
Journal ArticleDOI
Oligomerization of the Murine Fatty Acid Transport Protein 1
M. Rachel Richards,Laura L. Listenberger,Alicia A. Kelly,Sarah E. Lewis,Daniel S. Ory,Jean E. Schaffer +5 more
TL;DR: Results are consistent with a model in which FATP1 homodimeric complexes play an important role in cellular fatty acid import, and it is shown that, when expressed in the same cells, differentially tagged FATP 1 proteins co-immunoprecipitate.