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Sarah J. Goodman
Researcher at University of Toronto
Publications - 9
Citations - 276
Sarah J. Goodman is an academic researcher from University of Toronto. The author has contributed to research in topics: dNaM & DNA methylation. The author has an hindex of 5, co-authored 9 publications receiving 142 citations. Previous affiliations of Sarah J. Goodman include University of Hong Kong.
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Journal ArticleDOI
Multilocus loss of DNA methylation in individuals with mutations in the histone H3 Lysine 4 Demethylase KDM5C
Daria Grafodatskaya,Barian H Y Chung,Darci T. Butcher,Andrei L. Turinsky,Sarah J. Goodman,Sana Choufani,Yi-an Chen,Youliang Lou,Chunhua Zhao,Rageen Rajendram,Fatima Abidi,Cindy Skinner,James Stavropoulos,Carolyn A. Bondy,Jill Hamilton,Shoshana J. Wodak,Stephen W. Scherer,Stephen W. Scherer,Charles E. Schwartz,Rosanna Weksberg +19 more
TL;DR: Genetic alterations in patient samples carrying a mutation in a gene involved in the regulation of histone modifications are identified, for the first time, and support the concept that DNA methylation and H3 lysine 4 methylation are functionally interdependent.
Journal ArticleDOI
DNA Methylation Signature for EZH2 Functionally Classifies Sequence Variants in Three PRC2 Complex Genes
Sanaa Choufani,William T. Gibson,Andrei L. Turinsky,Brian H.Y. Chung,Tianren Wang,Kopal Garg,Alessandro Vitriolo,Ana S A Cohen,Ana S A Cohen,Sharri Cyrus,Sarah J. Goodman,Eric Chater-Diehl,Jack Brzezinski,Michael Brudno,Luk Ho Ming,Susan M. White,Sally Ann Lynch,Carol L. Clericuzio,I. Karen Temple,Frances Flinter,Vivienne McConnell,Tom Cushing,Lynne M. Bird,Miranda Splitt,Bronwyn Kerr,Stephen W. Scherer,Jerry Machado,Eri Imagawa,Nobuhiko Okamoto,Naomichi Matsumoto,Guiseppe Testa,Maria Iascone,Romano Tenconi,Oana Caluseriu,Roberto Mendoza-Londono,David Chitayat,David Chitayat,Cheryl Cytrynbaum,Katrina Tatton-Brown,Rosanna Weksberg +39 more
TL;DR: The discovery of a functionally relevant signature with utility for diagnostic classification of sequence variants in EZH2, EED, and SUZ12 supports the emerging paradigm shift for implementation of DNAm signatures into diagnostics and translational research.
Journal ArticleDOI
Anatomy of DNA methylation signatures: Emerging insights and applications.
Eric Chater-Diehl,Sarah J. Goodman,Cheryl Cytrynbaum,Andrei L. Turinsky,Sanaa Choufani,Rosanna Weksberg +5 more
TL;DR: The potential of DNA methylation signatures (also known as "episignatures") is just beginning to emerge as there are >300 known epigenetic regulatory genes, ∼100 of which are linked to neurodevelopmental disorders.
Journal ArticleDOI
New insights into DNA methylation signatures: SMARCA2 variants in Nicolaides-Baraitser syndrome
Eric Chater-Diehl,Resham Ejaz,Cheryl Cytrynbaum,Michelle T. Siu,Andrei L. Turinsky,Sanaa Choufani,Sarah J. Goodman,Omar A. Abdul-Rahman,Melanie Bedford,Melanie Bedford,Naghmeh Dorrani,Kendra Engleman,Josue Flores-Daboub,David Geneviève,Roberto Mendoza-Londono,Wendy S. Meschino,Laurence Perrin,Nicole P. Safina,Nicole P. Safina,Sharron Townshend,Stephen W. Scherer,Evdokia Anagnostou,Evdokia Anagnostou,Amélie Piton,Matthew A. Deardorff,Matthew A. Deardorff,Michael Brudno,David Chitayat,David Chitayat,Rosanna Weksberg +29 more
TL;DR: A DNAm signature of SMarCA2 pathogenic variants in NCBRS maps to CpGs relevant to disorder pathophysiology, classifies VUS, and is sensitive to the position of the variant in SMARCA2, demonstrating the precision with which they can reflect genotypic variation.
Journal ArticleDOI
DNA Methylation of the Oxytocin Receptor Across Neurodevelopmental Disorders.
Michelle T. Siu,Michelle T. Siu,Sarah J. Goodman,Isaac Yellan,Darci T. Butcher,Maryam Jangjoo,Daria Grafodatskaya,Rageen Rajendram,Youliang Lou,Rujun Zhang,Chunhua Zhao,Rob Nicolson,Stelios Georgiades,Peter Szatmari,Peter Szatmari,Stephen W. Scherer,Wendy Roberts,Evdokia Anagnostou,Evdokia Anagnostou,Rosanna Weksberg +19 more
TL;DR: For example, the authors examined DNA methylation in the 1st intron of the OXTR gene in patients with autism spectrum (ASD), attention deficit and hyperactivity (ADHD) and obsessive compulsive (OCD) disorders.