S
Sarah J. Nelson
Researcher at University of California, San Francisco
Publications - 292
Citations - 24417
Sarah J. Nelson is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Magnetic resonance spectroscopic imaging & Magnetic resonance imaging. The author has an hindex of 86, co-authored 291 publications receiving 22507 citations. Previous affiliations of Sarah J. Nelson include University of California & University of California, Berkeley.
Papers
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Journal ArticleDOI
Magnetic Resonance of 2-Hydroxyglutarate in IDH1-Mutated Low-Grade Gliomas
Adam Elkhaled,Llewellyn E. Jalbert,Joanna J. Phillips,Hikari A. I. Yoshihara,Rupa Parvataneni,Radhika Srinivasan,Gabriela Bourne,Mitchel S. Berger,Susan M. Chang,Soonmee Cha,Sarah J. Nelson +10 more
TL;DR: Ex vivo detection of 2HG in IDH1-mutated tissue samples from patients with recurrent low-grade gliomas shows that the use of magnetic resonance imaging technology, already routine in the clinic, could significantly improve the management of brain tumors.
Journal ArticleDOI
Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo
David M. Wilson,Kayvan R. Keshari,Kayvan R. Keshari,Peder E. Z. Larson,Albert P. Chen,Simon Hu,Mark Van Criekinge,Robert Bok,Sarah J. Nelson,Jeffrey M. Macdonald,Daniel B. Vigneron,John Kurhanewicz +11 more
TL;DR: The feasibility of simultaneously measuring in vivo pH and tumor metabolism using nontoxic, endogenous species, and the potential to extend the multi-polarization approach to include up to four hyperpolarized probes providing multiple metabolic and physiologic measures in a single MR acquisition are demonstrated.
Journal Article
Dynamic susceptibility-weighted perfusion imaging of high-grade gliomas : Characterization of spatial heterogeneity
TL;DR: In this article, peak height and percent recovery of the T2* relaxivity curve were used to characterize angiogenesis and microvascular leakage within T2 and contrast-enhancing abnormalities in high-grade gliomas.
Journal ArticleDOI
Genotype–Phenotype correlations in multiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures
Darin T. Okuda,Radhika Srinivasan,Jorge R. Oksenberg,Douglas S. Goodin,Sergio E. Baranzini,A. Beheshtian,Emmanuelle Waubant,Scott S. Zamvil,David Leppert,Pamela Qualley,Robin R. Lincoln,Refujia Gomez,Stacy J. Caillier,Michaela F. George,J. Wang,Sarah J. Nelson,Bruce A.C. Cree,Stephen L. Hauser,Daniel Pelletier +18 more
TL;DR: It is suggested that DRB1*1501 increases disease severity in MS by facilitating the development of more T2-foci, thereby increasing the potential for irreversible axonal compromise and subsequent neuronal degeneration, as suggested by the reduction of NAA concentrations in NAWM, ultimately leading to a decline in brain volume.
Journal Article
Serial Proton MR Spectroscopic Imaging of Recurrent Malignant Gliomas after Gamma Knife Radiosurgery
Edward E. Graves,Sarah J. Nelson,Daniel B. Vigneron,Lynn Verhey,Michael W. McDermott,David A. Larson,Susan M. Chang,Michael D. Prados,William P. Dillon +8 more
TL;DR: Evaluation of metabolic changes with proton MR spectroscopy and structural changes with MR imaging improved tissue discrimination and provided correlation with histologic findings.