S
Sarah L. Jongbloed
Publications - 5
Citations - 1883
Sarah L. Jongbloed is an academic researcher. The author has contributed to research in topics: Antigen & Cytotoxic T cell. The author has an hindex of 5, co-authored 5 publications receiving 1767 citations.
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Journal ArticleDOI
Human CD141(+) (BDCA-3)(+) dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens
Sarah L. Jongbloed,Andrew J. Kassianos,Kylie J. McDonald,Georgina J. Clark,Xinsheng Ju,Catherine E. Angel,Chun-Jen J. Chen,P. Rod Dunbar,Robert Wadley,Varinder Jeet,Annelie J.E. Vulink,Derek N.J. Hart,Derek N.J. Hart,Kristen J. Radford +13 more
TL;DR: In this paper, the authors report the first detailed functional analysis of the human CD141+ DC subset, which is found in human lymph nodes, bone marrow, tonsil, and blood, and the latter proved to be the best source of highly purified cells for functional analysis.
Human CD141(+) (BDCA-3)(+) dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens
Sarah L. Jongbloed,Andrew J. Kassianos,Kylie J. McDonald,Georgina J. Clark,Xinsheng Ju,Catherine E. Angel,Chun-Jen J. Chen,P. Rod Dunbar,Robert Wadley,Varinder Jeet,Annelie J.E. Vulink,Derek N.J. Hart,Derek N.J. Hart,Kristen J. Radford +13 more
TL;DR: The data demonstrate a role for CD141+ DCs in the induction of cytotoxic T lymphocyte responses and suggest that they may be the most relevant targets for vaccination against cancers, viruses, and other pathogens.
Journal ArticleDOI
Human CD1c (BDCA-1)+ myeloid dendritic cells secrete IL-10 and display an immuno-regulatory phenotype and function in response to Escherichia coli.
Andrew J. Kassianos,Melinda Y. Hardy,Xinsheng Ju,Dipti Vijayan,Yitian Ding,Annelie J.E. Vulink,Kylie J. McDonald,Sarah L. Jongbloed,Robert Wadley,Christine A. Wells,Derek N.J. Hart,Kristen J. Radford +11 more
TL;DR: Compared to their mouse CD8+ DC counterparts, human CD141+ DCs did not phagocytose or process E. coli‐derived Ag and failed to secrete cytokines in response to E.E. coli.
Book ChapterDOI
Isolation of Human Blood DC Subtypes
TL;DR: Human blood dendritic cells are a rare, heterogeneous cell population that comprise approximately 1% of circulating peripheral blood mononuclear cells (PBMCs) and their isolation has been confounded by their scarcity and lack of distinguishing markers.
Journal ArticleDOI
NK cells enhance the induction of CTL responses by IL-15 monocyte-derived dendritic cells
Melinda Y. Hardy,Andrew J. Kassianos,Annelie J.E. Vulink,Ray Wilkinson,Sarah L. Jongbloed,Derek N.J. Hart,Kristen J. Radford +6 more
TL;DR: Data implicate a role for small percentages of NK cells in the enhanced capacity of IL‐15 MoDC to induce tumour‐specific CTL independent ofIL‐12p70, and suggest these cells are promising candidates for DC immunotherapy.