C
Chun-Jen J. Chen
Researcher at University of Auckland
Publications - 16
Citations - 2076
Chun-Jen J. Chen is an academic researcher from University of Auckland. The author has contributed to research in topics: Population & Antigen-presenting cell. The author has an hindex of 9, co-authored 14 publications receiving 1925 citations.
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Journal ArticleDOI
Human CD141(+) (BDCA-3)(+) dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens
Sarah L. Jongbloed,Andrew J. Kassianos,Kylie J. McDonald,Georgina J. Clark,Xinsheng Ju,Catherine E. Angel,Chun-Jen J. Chen,P. Rod Dunbar,Robert Wadley,Varinder Jeet,Annelie J.E. Vulink,Derek N.J. Hart,Derek N.J. Hart,Kristen J. Radford +13 more
TL;DR: In this paper, the authors report the first detailed functional analysis of the human CD141+ DC subset, which is found in human lymph nodes, bone marrow, tonsil, and blood, and the latter proved to be the best source of highly purified cells for functional analysis.
Human CD141(+) (BDCA-3)(+) dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens
Sarah L. Jongbloed,Andrew J. Kassianos,Kylie J. McDonald,Georgina J. Clark,Xinsheng Ju,Catherine E. Angel,Chun-Jen J. Chen,P. Rod Dunbar,Robert Wadley,Varinder Jeet,Annelie J.E. Vulink,Derek N.J. Hart,Derek N.J. Hart,Kristen J. Radford +13 more
TL;DR: The data demonstrate a role for CD141+ DCs in the induction of cytotoxic T lymphocyte responses and suggest that they may be the most relevant targets for vaccination against cancers, viruses, and other pathogens.
Journal ArticleDOI
CD14+ antigen-presenting cells in human dermis are less mature than their CD1a+ counterparts.
Catherine E. Angel,Aisha Lala,Chun-Jen J. Chen,Stephen G. Edgar,Lena Ostrovsky,P. Rod Dunbar +5 more
TL;DR: CD14(+) dermal APCs are therefore the dominant cutaneous APC population capable of sensing ligands recognized by CD206, CD209 and TLR2 and subsequently may have the potential to mature.
Journal ArticleDOI
Distinctive localization of antigen-presenting cells in human lymph nodes
Catherine E. Angel,Chun-Jen J. Chen,Oliver Horlacher,Sintia Winkler,Thomas John,Judy Browning,Duncan MacGregor,Jonathan Cebon,P. Rod Dunbar +8 more
TL;DR: Using 3-color immunohistochemistry, the identification of 2 distinct APC populations in the paracortex of human lymph nodes has important implications for understanding T-lymphocyte responses and optimizing vaccine design.
Journal ArticleDOI
Neutrophil influx and chemokine production during the early phases of the antitumor response to the vascular disrupting agent DMXAA (ASA404).
Liang-Chuan S. Wang,Lotte Thomsen,Rachel Sutherland,Charu B. Reddy,Sofian M. Tijono,Chun-Jen J. Chen,Catherine E. Angel,P. Rod Dunbar,Lai-Ming Ching +8 more
TL;DR: 5,6-Dimethylxanthenone-4-acetic acid acts through tumor vascular disruption and cytokine production and is the first of its class to enter phase 3 trials and characterized leukocytes and cytokines in murine Colon 38 tumors before and after DMXAA treatment.