K
Kylie J. McDonald
Researcher at University of Queensland
Publications - 6
Citations - 1939
Kylie J. McDonald is an academic researcher from University of Queensland. The author has contributed to research in topics: Antigen & Cytotoxic T cell. The author has an hindex of 5, co-authored 6 publications receiving 1813 citations.
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Journal ArticleDOI
Human CD141(+) (BDCA-3)(+) dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens
Sarah L. Jongbloed,Andrew J. Kassianos,Kylie J. McDonald,Georgina J. Clark,Xinsheng Ju,Catherine E. Angel,Chun-Jen J. Chen,P. Rod Dunbar,Robert Wadley,Varinder Jeet,Annelie J.E. Vulink,Derek N.J. Hart,Derek N.J. Hart,Kristen J. Radford +13 more
TL;DR: In this paper, the authors report the first detailed functional analysis of the human CD141+ DC subset, which is found in human lymph nodes, bone marrow, tonsil, and blood, and the latter proved to be the best source of highly purified cells for functional analysis.
Human CD141(+) (BDCA-3)(+) dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens
Sarah L. Jongbloed,Andrew J. Kassianos,Kylie J. McDonald,Georgina J. Clark,Xinsheng Ju,Catherine E. Angel,Chun-Jen J. Chen,P. Rod Dunbar,Robert Wadley,Varinder Jeet,Annelie J.E. Vulink,Derek N.J. Hart,Derek N.J. Hart,Kristen J. Radford +13 more
TL;DR: The data demonstrate a role for CD141+ DCs in the induction of cytotoxic T lymphocyte responses and suggest that they may be the most relevant targets for vaccination against cancers, viruses, and other pathogens.
Journal ArticleDOI
Human CD1c (BDCA-1)+ myeloid dendritic cells secrete IL-10 and display an immuno-regulatory phenotype and function in response to Escherichia coli.
Andrew J. Kassianos,Melinda Y. Hardy,Xinsheng Ju,Dipti Vijayan,Yitian Ding,Annelie J.E. Vulink,Kylie J. McDonald,Sarah L. Jongbloed,Robert Wadley,Christine A. Wells,Derek N.J. Hart,Kristen J. Radford +11 more
TL;DR: Compared to their mouse CD8+ DC counterparts, human CD141+ DCs did not phagocytose or process E. coli‐derived Ag and failed to secrete cytokines in response to E.E. coli.
Journal ArticleDOI
Enhanced delivery of immunoliposomes to human dendritic cells by targeting the multilectin receptor DEC-205.
Ali Badiee,Nigel M. Davies,Kylie J. McDonald,Kristen J. Radford,Hiroaki Michiue,Derek N.J. Hart,Masato Kato +6 more
TL;DR: Dendritic cells (DC) are specialized white blood cells that initiate and direct immune responses and DEC-205 is an effective target for delivering liposomes to human DC.
Journal ArticleDOI
Differential uptake and cross‐presentation of soluble and necrotic cell antigen by human DC subsets
Meng-Chieh Chiang,Kirsteen M. Tullett,Kirsteen M. Tullett,Yoke Seng Lee,Adi Idris,Yitian Ding,Kylie J. McDonald,Andrew J. Kassianos,Ingrid M. Leal Rojas,Varinder Jeet,Mireille H. Lahoud,Mireille H. Lahoud,Kristen J. Radford +12 more
TL;DR: It is demonstrated that human CD141+ DCs, like their murine CD8α+ DC counterparts, are specialized at cross‐presenting cellular Ag, most likely mediated by an enhanced capacity to ingest cellular Ag combined with subtle changes in lysosomal pH during Ag processing and use of the cytosolic pathway.