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Sarah Toscano
Researcher at Max Planck Society
Publications - 7
Citations - 340
Sarah Toscano is an academic researcher from Max Planck Society. The author has contributed to research in topics: Dosage compensation & Genome. The author has an hindex of 6, co-authored 7 publications receiving 284 citations. Previous affiliations of Sarah Toscano include Babraham Institute.
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Journal ArticleDOI
Tandem stem-loops in roX RNAs act together to mediate X chromosome dosage compensation in Drosophila.
Ibrahim Avsar Ilik,Jeffrey J. Quinn,Plamen Georgiev,Filipe Tavares-Cadete,Daniel Maticzka,Sarah Toscano,Yue Wan,Robert C. Spitale,Nicholas M. Luscombe,Rolf Backofen,Rolf Backofen,Howard Y. Chang,Asifa Akhtar +12 more
TL;DR: It is proposed that repetitive structural motifs in lncRNAs could provide plasticity during multiprotein complex assemblies to ensure efficient targeting in cis or in trans along chromosomes.
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High-Affinity Sites Form an Interaction Network to Facilitate Spreading of the MSL Complex across the X Chromosome in Drosophila
Fidel Ramírez,Thomas Lingg,Thomas Lingg,Sarah Toscano,Kin Chung Lam,Kin Chung Lam,Plamen Georgiev,Ho-Ryun Chung,Bryan R. Lajoie,Elzo de Wit,Ye Zhan,Wouter de Laat,Job Dekker,Job Dekker,Thomas Manke,Asifa Akhtar +15 more
TL;DR: It is proposed that the sex-independent, three-dimensional conformation of the X chromosome poises it for exploitation by the MSL complex, thereby facilitating spreading in males.
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Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) regulates TOR signaling and cell growth during Drosophila development
Amit Gupta,Sarah Toscano,Deepti Trivedi,David R. Jones,Swarna Mathre,Jonathan H. Clarke,Nullin Divecha,Padinjat Raghu,Padinjat Raghu +8 more
TL;DR: Drosophila phosphatidylinositol 5-phosphate 4-kinase (dPIP4K) is identified as a phosphoinositide kinase that regulates growth during larval development and changes in the signaling input into the target of rapamycin (TOR) signaling complex are revealed.
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Hi-C guided assemblies reveal conserved regulatory topologies on X and autosomes despite extensive genome shuffling
Gina Renschler,Gina Renschler,Gautier Richard,Gautier Richard,Claudia Isabelle Keller Valsecchi,Sarah Toscano,Laura Arrigoni,Fidel Ramírez,Asifa Akhtar +8 more
TL;DR: The authors developed a scaffolding algorithm and generated chromosome-length assemblies from Hi-C data for studying genome topology in three distantly related Drosophila species, which provides unique insights into genomeTopology evolution.
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Phosphatidylinositol 5-phosphate 4-kinase regulates early endosomal dynamics during clathrin-mediated endocytosis.
Kumari Kamalesh,Kumari Kamalesh,Deepti Trivedi,Sarah Toscano,Sanjeev Sharma,Sourav Kolay,Sourav Kolay,Padinjat Raghu +7 more
TL;DR: PIP4K is defined as a novel regulator of early endosomal homeostasis during CME, which regulates early endOSomal dynamics and trafficking of plasma membrane receptors through clathrin-mediated endocytosis in Drosophila cells.