S
Saskia S. Arndt
Researcher at Utrecht University
Publications - 54
Citations - 1719
Saskia S. Arndt is an academic researcher from Utrecht University. The author has contributed to research in topics: Habituation & Biology. The author has an hindex of 17, co-authored 46 publications receiving 1505 citations. Previous affiliations of Saskia S. Arndt include University of Cologne.
Papers
More filters
Journal ArticleDOI
Role for neuronal insulin resistance in neurodegenerative diseases
Markus Schubert,Dinesh Gautam,David Surjo,Kazuhiro Ueki,S. Baudler,D. Schubert,Tatsuya Kondo,Jens Alber,Norbert Galldiks,Ekkehard Küstermann,Saskia S. Arndt,Andreas H. Jacobs,Wilhelm Krone,C R Kahn,Jens C. Brüning +14 more
TL;DR: Analysis of brain/neuron-specific insulin receptor knockout mice finds that NIRKO mice exhibit a complete loss of insulin-mediated activation of phosphatidylinositol 3-kinase and inhibition of neuronal apoptosis, which may lead to changes in Akt and GSK3β activity and Tau hyperphosphorylation.
Journal ArticleDOI
Evaluation of animal models of neurobehavioral disorders
TL;DR: The developmental and evaluation procedure itself may be improved by careful definition of the purpose(s) of a model and by defining better evaluation criteria, based on the proposed use of the model, in a manner congruent to that for improving animal models.
Journal ArticleDOI
Individual housing of mice ― Impact on behaviour and stress responses
Saskia S. Arndt,Marijke C. Laarakker,Hein A. van Lith,F. Josef van der Staay,Elise T. Gieling,Amber R. Salomons,José van’t Klooster,Frauke Ohl +7 more
TL;DR: Neither male nor female mice housed individually showed stronger signs of stress than their socially-housed counterparts, however, it is observed a within-cage order effect on the hormonal stress response (corticosterone) in socially-Housed female C57BL/6 mice.
Journal ArticleDOI
Pathological anxiety in animals.
TL;DR: A definition is suggested and the potential causes of pathological anxiety are explored with a plea for developing adequate diagnostic tools and therapies to fight pathological anxiety in animals based on insight from scientific research.
Journal ArticleDOI
A test to identify judgement bias in mice
Hetty Boleij,José van’t Klooster,Marla Lavrijsen,Susanne Kirchhoff,Saskia S. Arndt,Frauke Ohl +5 more
TL;DR: The behavioural results suggest that the present judgement bias test might be used to assess emotional states in at least BALB/c mice, however further research on both behaviour and on the involved brain mechanisms is necessary to confirm this idea.