M
Markus Schubert
Researcher at University of Cologne
Publications - 58
Citations - 7518
Markus Schubert is an academic researcher from University of Cologne. The author has contributed to research in topics: Insulin receptor & Insulin. The author has an hindex of 29, co-authored 57 publications receiving 7050 citations. Previous affiliations of Markus Schubert include Howard Hughes Medical Institute & Harvard University.
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Journal ArticleDOI
Role of Brain Insulin Receptor in Control of Body Weight and Reproduction
Jens C. Brüning,Dinesh Gautam,Deborah J. Burks,Jennifer A. Gillette,Markus Schubert,Paul C. Orban,Rüdiger Klein,Wilhelm Krone,Dirk Müller-Wieland,C. Ronald Kahn +9 more
TL;DR: Mice created with a neuron-specific disruption of the IR gene showed increased food intake, and both male and female mice developed diet-sensitive obesity with increases in body fat and plasma leptin levels, mild insulin resistance, elevated plasma insulin levels, and hypertriglyceridemia.
Journal ArticleDOI
STAT3 signalling is required for leptin regulation of energy balance but not reproduction.
Sarah H. Bates,Walter H. Stearns,Trevor A. Dundon,Markus Schubert,Annette W. K. Tso,Yongping Wang,Alexander S. Banks,Hugh J. Lavery,Asma K. Haq,Eleftheria Maratos-Flier,Benjamin G. Neel,Michael W. Schwartz,Martin G. Myers +12 more
TL;DR: It is shown that, like db/db mice, leprS1138 homozygotes (s/s) are hyperphagic and obese, however, whereas db/ db mice are infertile, short and diabetic, s/s mice are fertile, long and less hyperglycaemic.
Journal ArticleDOI
The role of insulin receptor signaling in the brain.
TL;DR: Insulin regulates phosphorylation of tau, metabolism of the amyloid precursor protein and clearance of beta-amyloid from the brain in vivo and indicates that neuronal IR signaling has a direct role in the link between energy homeostasis, reproduction and the development of neurodegenerative diseases.
Journal ArticleDOI
Role for neuronal insulin resistance in neurodegenerative diseases
Markus Schubert,Dinesh Gautam,David Surjo,Kazuhiro Ueki,S. Baudler,D. Schubert,Tatsuya Kondo,Jens Alber,Norbert Galldiks,Ekkehard Küstermann,Saskia S. Arndt,Andreas H. Jacobs,Wilhelm Krone,C R Kahn,Jens C. Brüning +14 more
TL;DR: Analysis of brain/neuron-specific insulin receptor knockout mice finds that NIRKO mice exhibit a complete loss of insulin-mediated activation of phosphatidylinositol 3-kinase and inhibition of neuronal apoptosis, which may lead to changes in Akt and GSK3β activity and Tau hyperphosphorylation.
Journal ArticleDOI
Insulin Receptor Substrate-2 Deficiency Impairs Brain Growth and Promotes Tau Phosphorylation
Markus Schubert,Derek P. Brazil,Deborah J. Burks,Jake A. Kushner,Jing Ye,Carrie L. Flint,Janet Farhang-Fallah,Pieter Dikkes,Xavier M. Warot,Carlos Rio,Gabriel Corfas,Morris F. White +11 more
TL;DR: Dysregulation of the Irs2 branch of the insulin-Igf-signaling cascade reveals a molecular link between diabetes and neurodegenerative disease.