Wilhelm Krone

TL;DR: Mice created with a neuron-specific disruption of the IR gene showed increased food intake, and both male and female mice developed diet-sensitive obesity with increases in body fat and plasma leptin levels, mild insulin resistance, elevated plasma insulin levels, and hypertriglyceridemia.

TL;DR: Analysis of brain/neuron-specific insulin receptor knockout mice finds that NIRKO mice exhibit a complete loss of insulin-mediated activation of phosphatidylinositol 3-kinase and inhibition of neuronal apoptosis, which may lead to changes in Akt and GSK3β activity and Tau hyperphosphorylation.

TL;DR: It is shown that POMC-specific disruption of Pten resulted in hyperphagia and sexually dimorphic diet-sensitive obesity, which indicates that PIP3-mediated signals are critical regulators of the melanocortin system via modulation of KATP channels.

TL;DR: It is concluded that hypogonadal men exhibit elevated OB levels that are normalized by substitution with T, and the only determinant of OB levels was the androgen/estrogen ratio, indicating a major influence of sex steroids on OB production.

TL;DR: Inhibition of IL-6 signalling improves insulin sensitivity in humans with immunological disease suggesting that elevated IL- 6 levels in type 2 diabetic subjects might be causally involved in the pathogenesis of insulin resistance.