Satoru Funamoto

TL;DR: It is shown that chemotaxis pathways are activated along the lateral sides of cells and PI3K can initiate pseudopod formation, providing evidence for a direct instructional role ofPI3K in leading edge formation.

TL;DR: Results strongly suggest that Aβ is generated through the stepwise processing of βCTF by γ-secretase, and that an induction period exists in the generation of peptides.

TL;DR: This review outlines the present understanding of Phosphoinositide 3-kinase's central and possibly pivotal role in establishing and maintaining cell polarity by regulating the subcellular localization and activation of downstream effectors that are essential for regulating cellPolarity and proper chemotaxis.

TL;DR: The authors showed that Aβ43 showed a higher propensity to aggregate and was more neurotoxic than Aβ42, and other pathogenic presenilin mutations also caused overproduction of Aβ 43 in a manner correlating with Aβ 42 and with the age of disease onset.

TL;DR: PhdA is an adaptor protein that regulates F-actin localization in response to chemoattractants and links PI3K to the control of F-Actin polymerization at the leading edge during pseudopod formation, and it is suggested that PKB and PhdA lie downstream fromPI3K and control different downstream effector pathways that are essential for proper chemotaxis.