S
Satoru Miyagi
Researcher at Chiba University
Publications - 51
Citations - 3091
Satoru Miyagi is an academic researcher from Chiba University. The author has contributed to research in topics: Stem cell & Progenitor cell. The author has an hindex of 28, co-authored 50 publications receiving 2819 citations. Previous affiliations of Satoru Miyagi include University of Copenhagen & Shimane University.
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Journal ArticleDOI
Identification of Sox-2 regulatory region which is under the control of Oct-3/4-Sox-2 complex.
Mizuho Tomioka,Masazumi Nishimoto,Satoru Miyagi,Tomoko Katayanagi,Nobutaka Fukui,Hitoshi Niwa,Masami Muramatsu,Akihiko Okuda +7 more
TL;DR: The regulatory regions of the Sox-2 gene are analyzed and two enhancers which stimulate transcription in ES cells as well as in embryonal carcinoma cells are identified which are able to stimulate transcription through the SRR2 element.
Journal ArticleDOI
Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells
Makiko Mochizuki-Kashio,Yuta Mishima,Satoru Miyagi,Masamitsu Negishi,Atsunori Saraya,Takaaki Konuma,Jun Shinga,Haruhiko Koseki,Atsushi Iwama +8 more
TL;DR: It is shown that Ezh2, a core component of PRC2, is essential for fetal, but not adult, HSCs, and that the reinforcement of PcG-mediated gene silencing occurs during the transition from proliferative fetal Hscs to quiescent adult H SCs.
Journal ArticleDOI
The Polycomb Gene Product BMI1 Contributes to the Maintenance of Tumor-Initiating Side Population Cells in Hepatocellular Carcinoma
Tetsuhiro Chiba,Satoru Miyagi,Atsunori Saraya,Ryutaro Aoki,Atsuyoshi Seki,Yohei Morita,Yutaka Yonemitsu,Osamu Yokosuka,Hideki Taniguchi,Hiromitsu Nakauchi,Atsushi Iwama +10 more
TL;DR: An important role is defined for BMI1 in the maintenance of tumor-initiating SP cells in HCC and it is suggested that BMI1 might be a novel therapeutic target for the eradication of cancer stem cells inHCC.
Journal ArticleDOI
Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia
Satomi Tanaka,Satoru Miyagi,Goro Sashida,Tetsuhiro Chiba,Jin Yuan,Makiko Mochizuki-Kashio,Yutaka Suzuki,Sumio Sugano,Chiaki Nakaseko,Koutaro Yokote,Haruhiko Koseki,Atsushi Iwama +11 more
TL;DR: It is suggested that Ezh2 inhibits differentiation programs in leukemic stem cells, thereby augmenting their leukemogenic activity.
Journal ArticleDOI
Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders
Tomoya Muto,Goro Sashida,Motohiko Oshima,George R. Wendt,Makiko Mochizuki-Kashio,Yasunobu Nagata,Masashi Sanada,Satoru Miyagi,Atsunori Saraya,Asuka Kamio,Genta Nagae,Chiaki Nakaseko,Koutaro Yokote,Kazuya Shimoda,Haruhiko Koseki,Yutaka Suzuki,Sumio Sugano,Hiroyuki Aburatani,Seishi Ogawa,Atsushi Iwama +19 more
TL;DR: Deletion of Ezh2 results in transcriptional repression of developmental regulator genes, derepression of oncogenic polycomb targets, and induction of MDS/MPN-like disease in mice that is exacerbated by concurrent deletion of Tet2.