O
Osamu Yokosuka
Researcher at Chiba University
Publications - 797
Citations - 26799
Osamu Yokosuka is an academic researcher from Chiba University. The author has contributed to research in topics: Hepatitis B virus & Hepatocellular carcinoma. The author has an hindex of 67, co-authored 786 publications receiving 23576 citations.
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Journal ArticleDOI
Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment (RESORCE): a randomised, double-blind, placebo-controlled, phase 3 trial
Jordi Bruix,Shukui Qin,Philippe Merle,Alessandro Granito,Yi Hsiang Huang,György Bodoky,Marc Pracht,Osamu Yokosuka,Olivier Rosmorduc,Valeriy Breder,René Gerolami,Gianluca Masi,Paul Ross,Tianqiang Song,Jean-Pierre Bronowicki,Isabelle Ollivier-Hourmand,Masatoshi Kudo,Ann-Lii Cheng,Josep M. Llovet,Josep M. Llovet,Josep M. Llovet,Richard S. Finn,Marie Aude Leberre,Annette Baumhauer,Gerold Meinhardt,Guohong Han +25 more
TL;DR: Regorafenib is the only systemic treatment shown to provide survival benefit in HCC patients progressing on sorafenIB treatment, and future trials should explore combinations of regorAFenib with other systemic agents and third-line treatments for patients who fail or who do not tolerate the sequence of sorafanib and regorafinib.
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Interferon Therapy Reduces the Risk for Hepatocellular Carcinoma: National Surveillance Program of Cirrhotic and Noncirrhotic Patients with Chronic Hepatitis C in Japan
Haruhiko Yoshida,Yasushi Shiratori,Mitsuhiko Moriyama,Yasuyuki Arakawa,Tatsuya Ide,Michio Sata,Osami Inoue,Michitami Yano,Motohiko Tanaka,Shigetoshi Fujiyama,Shuhei Nishiguchi,Tetsuo Kuroki,Fumio Imazeki,Osamu Yokosuka,Shingo Kinoyama,Gotaro Yamada,Masao Omata +16 more
TL;DR: An analysis of the effect of interferon therapy on the incidence and prevention of hepatocellular carcinoma in patients with chronic hepatitis C who have undergone liver biopsy at one of eight participating institutions supported by the Japan Ministry of Health and Welfare.
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Histologic Improvement of Fibrosis in Patients with Hepatitis C Who Have Sustained Response to Interferon Therapy
Yasushi Shiratori,Fumio Imazeki,Mitsuhiko Moriyama,Michitami Yano,Yasuyuki Arakawa,Osamu Yokosuka,Tetsuo Kuroki,Shuhei Nishiguchi,Michio Sata,Gotarou Yamada,Shigetoshi Fujiyama,Haruhiko Yoshida,Masao Omata +12 more
TL;DR: WhetherInterferon therapy was associated with regression of histologic fibrosis in 593 patients, a subset of whom received interferon, by using paired biopsy samples obtained 1 to 10 years apart is examined.
Journal ArticleDOI
Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties.
Tetsuhiro Chiba,Kaoru Kita,Yun-Wen Zheng,Osamu Yokosuka,Hiromitsu Saisho,Atsushi Iwama,Hiromitsu Nakauchi,Hideki Taniguchi,Hideki Taniguchi +8 more
TL;DR: It is proposed that a minority population, detected as SP cells in HCC cells, possess extreme tumorigenic potential and provide heterogeneity to the cancer stem cell system characterized by distinct hierarchy.
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Mutations in the Precore Region of Hepatitis B Virus DNA in Patients with Fulminant and Severe Hepatitis
TL;DR: The presence of a mutant viral strain is associated with and may be involved in the pathogenesis of fulminant hepatitis B and severe exacerbations of chronic hepatitis B.