Saúl Gómez-Manzo

TL;DR: The state of the art in G6PD deficiency is reviewed, describing 217 mutations in the g6pd gene and it is found that class I mutations have the most deleterious effects on the structure and stability of the protein.

TL;DR: A successful over-expression method is developed that constitutes an easier and more precise method for obtaining and characterizing these enzymes.

TL;DR: Structural and functional studies were performed and it was found that the Cys222 derivatization is responsible for GlTIM inactivation, which indicates that the surrounding environment of each Cys residue has unique structural differences that can be exploited to design specific antigiardiasic drugs.

TL;DR: Reversed-phase high-pressure liquid chromatography and electron paramagnetic resonance spectroscopy led to the unequivocal presence of a pyrroloquinoline quinone prosthetic group associated with an ALDH complex from acetic acid bacteria, suggesting an intramolecular redox sequence that delivers electrons to the membrane ubiquinone.

TL;DR: It is demonstrated that rabeprazole is the most potent PPI for GlTIM inactivation and that all PPIs tested have substantial abilities to alter GITIM at the structural level, causing serious damage.