S
Saurabh Kumar
Researcher at Department of Biotechnology
Publications - 7
Citations - 61
Saurabh Kumar is an academic researcher from Department of Biotechnology. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 1, co-authored 4 publications receiving 22 citations.
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Journal ArticleDOI
Synthesis, characterization, and mechanistic studies of a gold nanoparticle-amphotericin B covalent conjugate with enhanced antileishmanial efficacy and reduced cytotoxicity.
Prakash Kumar,Pushkar Shivam,Saptarshi Mandal,Pragya Prasanna,Saurabh Kumar,Surendra Prasad,Ashish Kumar,Prolay Das,Vahab Ali,Shubhankar K. Singh,Debabrata Mandal +10 more
TL;DR: GNP-based delivery of AmB can be a better, cheaper, and safer alternative than available AmB formulations, and improved antileishmanial efficacy and reduced cytotoxicity.
Journal ArticleDOI
Current status of nanoscale drug delivery and the future of nano-vaccine development for leishmaniasis - A review.
Pragya Prasanna,Prakash Kumar,Saurabh Kumar,Vinod Kumar Rajana,Vishnu Kant,Surendra Prasad,Utpal Mohan,Velayutham Ravichandiran,Debabrata Mandal +8 more
TL;DR: In this article, the role of physicochemical properties of a nanoscale delivery system is discussed and different ways of nano-formulation delivery ranging from liposome, niosomes, polymeric, metallic, solid-lipid NPs were updated along with the possible mechanisms of action against the parasite.
Journal ArticleDOI
7,8-dihydroxyflavone-functionalized gold nanoparticles target the arginase enzyme of Leishmania donovani.
Pragya Prasanna,Prakash Kumar,Saptarshi Mandal,Tanvi Payal,Saurabh Kumar,Sk. Ugir Hossain,Prolay Das,V Ravichandiran,Debabrata Mandal +8 more
TL;DR: In this article, the efficacy and possible mechanism of action of 7,8-dihydroxyflavone (DHF) and DHF synthesized gold nanoparticles (GNPs) against the parasite Leishmania donovani were analyzed.
Journal ArticleDOI
Quebrachitol from Putranjiva roxburghii Wall. (Putranjivaceae) a potent antimalarial: Pre-clinical efficacy and its interaction with PfLDH.
Sonal Mishra,Saurabh Kumar,Ramdas,Sonam Khare,Aparna Wagle Shukla,K. Shanker,A. Pal,Feroz Khan,Mahendra P. Darokar +8 more
TL;DR: In this paper , two phytochemicals, viz. 2, 4 dihydroxy-5-(hydroxymethyl) benzoic acid (DHMBA), and quebrachitol (QBC), were identified with anti-parasitic activity.
Posted ContentDOI
Synthesis of 7, 8 –dihydroxyflavone functionalized gold nanoparticles and its mechanism of action against Leishmania donovani
Pragya Prasanna,Prakash Kumar,Saptarshi Mandal,Saurabh Kumar,Tanvi Payal,Ugir Hossain Sk.,Prolay Das,V. Ravichandiran,Debabrata Mandal +8 more
TL;DR: Low cytotoxicity and high biological activity may provide an alternative but improved delivery of DHF whose solubility increases due to conjugation with GNP, which is equally effective against sensitive and drug-resistant strains of L. donovani.