Sava Sakadžić

TL;DR: This work reports to their knowledge the first practical in vivo two-photon high-resolution pO2 measurements in small rodents' cortical microvasculature and tissue, made possible by combining an optimized imaging system with a two-Photon–enhanced phosphorescent nanoprobe.

TL;DR: It is shown that pericyte degeneration diminishes global and individual capillary CBF responses to neuronal stimuli, resulting in neurovascular uncoupling, reduced oxygen supply to the brain and metabolic stress.

TL;DR: It is shown that OCT estimates of absolute CBF values in rats agree with prior measures by autoradiography, suggesting that Doppler OCT can perform absolute flow measurements in animal models.

TL;DR: In this paper, a quantitative model for the effect of static tissue on velocity sensitivity was developed and validated using three-dimensional Doppler Optical Coherence Tomography and cranial window preparations.

TL;DR: Oxy-sensitive two-photon microscopy is used to measure the BOLD-relevant microvascular physiology occurring within a typical rodent fMRI voxel and predict the Bold signal from first principles using those measurements, which are illustrated by quantifying variations inThe BOLD signal induced by the morphological folding of the human cortex.