M.L. Bouthenet

TL;DR: H1-receptors are present in all areas and layers with a higher density in lamina IV of the cerebral cortex and in the hippocampal formation, and are the most abundant in the dentate gyrus and in several areas of the subiculum and commissural complex.

TL;DR: A photoaffinity probe derived from 125I-APT was covalently incorporated in several peptides, among which the labeling of two peptides of 59 and 32 kDa was prevented by H2 antagonists, suggesting that they correspond to H2-receptor binding peptides or proteolysis products of the latter.

TL;DR: There was transient and roughly concomitant expression of both D-2 receptors and tyrosine hydroxylase immunoreactivity in some areas such as spinal ganglia or the lateral ventricle floor, consistent with a possible development function of dopamine mediated by D- 2 receptors.

TL;DR: The widespread distribution of the H2 receptor, namely in thalamic nuclei or in telencephalic areas such as most layers of the cerebral cortex, together with its excitatory role previously established in electrophysiological studies, support its alleged function in mediating the histamine-driven control of arousal mechanisms.

TL;DR: The metallopeptidase enkephalinase known to participate in the inactivation of endogenous enkephalins and, possibly, other neuropeptides such as tachykinins, was visualized by autoradiography using a [125I]iodinated monoclonal antibody.