Scott A. Meyer

TL;DR: Results from this in vivo longitudinal study demonstrate retinal neuronal layer thinning following acute optic neuritis, corroborating the hypothesis that axonal injury may cause neuronal pathology in multiple sclerosis and suggesting the potential utility of quantitative optical coherence tomography retinal layer segmentation to monitor neuroprotective effects of novel agents in therapeutic trials.

TL;DR: Findings support the possibility of primary retinal pathology in a subset of patients with multiple sclerosis in whom there appears to be disproportionate thinning of the inner and outer nuclear layers, which may be occurring as a primary process independent of optic nerve pathology.

TL;DR: OCT segmentation demonstrates in vivo GCIP thinning in all MS subtypes, and GCIP thickness demonstrates better structure-function correlations (with vision and disability) in MS than RNFL thickness.

TL;DR: The findings suggest that retinal changes in MS reflect global CNS processes, and that OCT-derived GCIP thickness measures may have utility as an outcome measure for assessing neuroprotective agents, particularly in early, active MS.

TL;DR: Retinal measures reflect global central nervous system pathology in multiple sclerosis, with thicknesses of discrete retinal layers each appearing to be associated with distinct central nervous System processes.