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Scott A. Ness
Researcher at University of New Mexico
Publications - 86
Citations - 4274
Scott A. Ness is an academic researcher from University of New Mexico. The author has contributed to research in topics: MYB & Transcription factor. The author has an hindex of 33, co-authored 80 publications receiving 3979 citations. Previous affiliations of Scott A. Ness include Karolinska Institutet & European Bioinformatics Institute.
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Journal ArticleDOI
The v-myb oncogene product binds to and activates the promyelocyte-specific mim-1 gene
TL;DR: This article used differential hybridization to screen for v-myb-regulated genes in cells transformed by a temperature-sensitive mutant of the oncogene and identified a new gene, mim-1, which encodes a specific expressed, secretable protein contained in the granules of both normal and vmybtransformed promyelocytes.
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Pim-1 Kinase and p100 Cooperate to Enhance c-Myb Activity
Joel D Leverson,Päivi J. Koskinen,Frank C. Orrico,Eeva-Marja Rainio,Katriina J Jalkanen,Ajeeta B. Dash,Robert N. Eisenman,Scott A. Ness +7 more
TL;DR: Pim-1 and p100 appear to be components of a novel signal transduction pathway affecting c-Myb activity, linking all three to the cytokine-regulated control of hematopoietic cell growth, differentiation, and apoptosis.
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Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types.
TL;DR: The results indicate that c-Myb and NF-M proteins act as a bipartite, combinatorial signal that regulates the expression of myeloid-specific genes, even in heterologous cell types.
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The NF-M transcription factor is related to C/EBP beta and plays a role in signal transduction, differentiation and leukemogenesis of avian myelomonocytic cells.
TL;DR: The cloning of NF‐M, a myeloid‐specific transcription factor related to C/EBP beta, which is a target of activated protein kinases is described, indicating thatNF‐M plays a key role in myelomonocytic differentiation, in signal transduction during macrophage activation and in the development of myelogenous leukemia.
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The EVES motif mediates both intermolecular and intramolecular regulation of c-Myb.
TL;DR: It is suggested that Myb is regulated by a novel mechanism in which intramolecular interactions and conformational changes control the intermolecular associations among Myb, p100, and the transcriptional apparatus.