Scott E. Loveless

TL;DR: Current and recently published work exploring immunomodulation by PFOA and PFOS are described, and potential PPARα independence indicates that future research must explore mechanisms of action of these compounds, including PPAR α -dependent and -independent pathways.

TL;DR: The results of the second and final phase of an international trial in which the performance of the assay has been evaluated using seven test materials in five independent laboratories confirm that the local lymph node assay is robust and yields equivalent results when performed independently.

TL;DR: In both rats and mice, the overall responses to the linear/branched and the linear forms of PFOA were similar, but the branched form appears to be less potent.

TL;DR: These studies demonstrate that the local lymph node assay is sufficiently robust to accommodate minor procedural and technical modifications without material changes in test performance.

TL;DR: Evaluated data indicate that the local lymph node assay is sufficiently robust to yield equivalent results when performed independently in separate laboratories and indicate also that the LLNA is of value in assessing the skin sensitization potential of topical medicaments.