T
Trevor Scobey
Researcher at University of North Carolina at Chapel Hill
Publications - 38
Citations - 4163
Trevor Scobey is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Virus & Coronavirus. The author has an hindex of 21, co-authored 29 publications receiving 2847 citations.
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Journal ArticleDOI
A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence
Vineet D. Menachery,Boyd Yount,Kari Debbink,Sudhakar Agnihothram,Lisa E. Gralinski,Jessica A. Plante,Rachel L. Graham,Trevor Scobey,Xing Yi Ge,Eric F. Donaldson,Scott H. Randell,Antonio Lanzavecchia,Wayne A. Marasco,Zhengli Li Shi,Ralph S. Baric +14 more
TL;DR: A potential risk of SARS-CoV re-emergence from viruses currently circulating in bat populations is suggested, and robust viral replication both in vitro and in vivo is demonstrated.
Journal ArticleDOI
A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice.
Sarah R. Leist,Kenneth H. Dinnon,Alexandra Schäfer,Longping V. Tse,Kenichi Okuda,Yixuan J. Hou,Ande West,Caitlin E. Edwards,Wes Sanders,Ethan J. Fritch,Kendra Gully,Trevor Scobey,Ariane J. Brown,Timothy P. Sheahan,Nathaniel J. Moorman,Richard C. Boucher,Lisa E. Gralinski,Stephanie A. Montgomery,Ralph S. Baric +18 more
TL;DR: A new mouse-adapted SARS-CoV-2 virus that captures multiple aspects of severe COVID-19 disease in standard laboratory mice is generated and characterized to provide a robust platform for studies of ALI and ARDS to evaluate vaccine and antiviral drug performance.
Journal ArticleDOI
SARS-like WIV1-CoV poised for human emergence
Vineet D. Menachery,Boyd Yount,Amy C. Sims,Kari Debbink,Sudhakar Agnihothram,Lisa E. Gralinski,Rachel L. Graham,Trevor Scobey,Jessica A. Plante,Scott R. Royal,Jesica Swanstrom,Timothy P. Sheahan,Raymond J. Pickles,Raymond J. Pickles,Davide Corti,Scott H. Randell,Antonio Lanzavecchia,Wayne A. Marasco,Ralph S. Baric,Ralph S. Baric +19 more
TL;DR: An approach that combines existing metagenomics data with reverse genetics to engineer reagents to evaluate emergence and pathogenic potential of circulating zoonotic viruses indicates that the WIV1-coronavirus (CoV) cluster has the ability to directly infect and may undergo limited transmission in human populations.
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Further Evidence for Bats as the Evolutionary Source of Middle East Respiratory Syndrome Coronavirus.
Simon J. Anthony,Simon J. Anthony,Kirsten V. K. Gilardi,Vineet D. Menachery,Tracey Goldstein,B. Ssebide,Ruth Mbabazi,Isamara Navarrete-Macias,Eliza Liang,Eliza Liang,Heather L. Wells,Allison L. Hicks,Alexandra Petrosov,Denis K. Byarugaba,Kari Debbink,Kenneth H. Dinnon,Trevor Scobey,Scott H. Randell,Boyd Yount,Michael R. Cranfield,Michael R. Cranfield,Christine K. Johnson,Ralph S. Baric,Walter Ian Lipkin,Jonna A. K. Mazet +24 more
TL;DR: A Mers-like CoV identified from a Pipistrellus cf.
Journal ArticleDOI
Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus
Trevor Scobey,Boyd Yount,Amy C. Sims,Eric F. Donaldson,Sudhakar Agnihothram,Vineet D. Menachery,Rachel L. Graham,Jesica Swanstrom,Peter F. Bove,Jeeho D. Kim,Sonia Grego,Scott H. Randell,Ralph S. Baric +12 more
TL;DR: In this paper, the authors synthesize a panel of contiguous cDNAs that spanned the entire genome, and transfected full-length transcripts recovered several recombinant viruses (rMERS-CoV) that contained the expected marker mutations inserted into the component clones.