Scott Ribich

TL;DR: It seems clear that deiodinases play a much broader role than once thought, with great ramifications for the control of thyroid hormone signaling during vertebrate development and metamorphosis, as well as injury response, tissue repair, hypothalamic function, and energy homeostasis in adults.

TL;DR: It is shown that each Pcdh variableExon is preceded by a promoter and that promoter choice determines which variable exon is included in a PCDh mRNA, providing evidence that alternative splicing of variable exons within a gene cluster occurs via a cis-splicing mechanism.

TL;DR: The Parkinson's disease-associated mutations have no effect on membrane interaction; however, the Ala-30 --> Pro mutation alters the three-dimensional conformation of alpha-synuclein, as measured by significantly increased fluorescence resonance energy transfer between the N and C termini.

TL;DR: It is shown that HS5–1 is required for maximal levels of expression from the PCDh α1–12 and αC1 promoters, but not the Pcdh-αC2 promoter, which is consistent with the possibility that the monoallelic expression of PcdH-α V exons is a consequence of competition between individual V exon promoters for the two regulatory elements.

TL;DR: It is reported that the adult D2KO BAT has a permanent thermogenic defect that stems from impaired embryonic BAT development and highlights the importance of deiodinase-controlled thyroid hormone signaling in BAT development, where it has important metabolic repercussions for energy homeostasis in adulthood.