R
Richard Axel
Researcher at Howard Hughes Medical Institute
Publications - 237
Citations - 53570
Richard Axel is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Gene & Olfactory system. The author has an hindex of 105, co-authored 235 publications receiving 51210 citations. Previous affiliations of Richard Axel include University of Texas Southwestern Medical Center & United States Department of Health and Human Services.
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Journal ArticleDOI
A novel multigene family may encode odorant receptors: A molecular basis for odor recognition
Linda B. Buck,Richard Axel +1 more
TL;DR: This work has cloned and characterized 18 different members of an extremely large multigene family that encodes seven transmembrane domain proteins whose expression is restricted to the olfactory epithelium and is likely to encode a diverse family of odorant receptors.
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The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain.
Paul J. Maddon,Angus G. Dalgleish,J. Steven McDougal,Paul R. Clapham,Robin A. Weiss,Richard Axel +5 more
TL;DR: The studies support a mechanism of AIDS virus infection that initially involves the specific interaction of theAIDS virus with T4 molecules on the cell surface, and find that the T4 gene is expressed in the brain as well as in lymphoid cells, providing an explanation for the dual neurotropic and lymphotropic character of the AIDS virus.
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Visualizing an Olfactory Sensory Map
Peter Mombaerts,Fan Wang,Catherine Dulac,Steve K. Chao,Adriana Nemes,Monica Mendelsohn,James Edmondson,Richard Axel +7 more
TL;DR: A genetic approach is developed to visualize axons from olfactory sensory neurons expressing a given odorant receptor, as they project to the Olfactory bulb, which provides direct support for a model in which a topographic map of receptor activation encodes odor quality in the ofactory bulb.
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Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells.
TL;DR: The results prove the usefulness of transfection assays as a means for the bioassay and isolation of restriction fragments carrying specific genetic information and cells expressing HSV-1 tk may also provide a useful model system for the detailed analysis of eucaryotic and viral gene regulation.
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Transformation of mammalian cells with genes from procaryotes and eucaryotes
Michael Wigler,Raymond W. Sweet,Gek Kee Sim,Barbara Wold,A. Pellicer,Elizabeth Lacy,Tom Maniatis,Saul Silverstein,Richard Axel +8 more
TL;DR: This co-transformation system should allow the introduction and stable integration of virtually any defined gene into cultured cells and is likely to represent a subpopulation of competent cells which are likely to integrate other unlinked genes at frequencies higher than the general population.