M
Marcelo A. Christoffolete
Researcher at Universidade Federal do ABC
Publications - 41
Citations - 3928
Marcelo A. Christoffolete is an academic researcher from Universidade Federal do ABC. The author has contributed to research in topics: Thermogenesis & Iodothyronine deiodinase. The author has an hindex of 22, co-authored 37 publications receiving 3524 citations. Previous affiliations of Marcelo A. Christoffolete include Harvard University & Brigham and Women's Hospital.
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Journal ArticleDOI
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
Mitsuhiro Watanabe,Sander M. Houten,Chikage Mataki,Marcelo A. Christoffolete,Brian W. Kim,Hiroyuki Sato,Nadia Messaddeq,John W. Harney,Osamu Ezaki,Tatsuhiko Kodama,Kristina Schoonjans,Antonio C. Bianco,Johan Auwerx +12 more
TL;DR: It is shown that the administration of BAs to mice increases energy expenditure in brown adipose tissue, preventing obesity and resistance to insulin, and indicates that BAs might be able to function beyond the control of BA homeostasis as general metabolic integrators.
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Perilipin Promotes Hormone-sensitive Lipase-mediated Adipocyte Lipolysis via Phosphorylation-dependent and -independent Mechanisms
Hideaki Miyoshi,Hideaki Miyoshi,Sandra C. Souza,Hui Hong Zhang,Katherine J. Strissel,Marcelo A. Christoffolete,Julia Kovsan,Assaf Rudich,Fredric B. Kraemer,Antonio C. Bianco,Martin S. Obin,Andrew S. Greenberg +11 more
TL;DR: It is demonstrated by cell fractionation and confocal microscopy that up to 50% of cellular HSL is LD-associated in the basal state and that PKA-stimulated HSL translocation is fully supported by adenoviral expression of a mutant perilipin lacking all six PKA sites (Peri AΔ1–6).
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The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate.
Monica Dentice,Amitabha Bandyopadhyay,Balázs Gereben,Isabelle Callebaut,Marcelo A. Christoffolete,Brian W. Kim,Sahar Nissim,Jean-Paul Mornon,Ann Marie Zavacki,Anikó Zeöld,Luciane P. Capelo,Cyntia Curcio-Morelli,Rogerio S. Ribeiro,John W. Harney,Clifford J. Tabin,Antonio C. Bianco +15 more
TL;DR: ECSWSB-1 mediates a mechanism by which 'systemic' thyroid hormone can effect local control of the Hedgehog–PTHrP negative feedback loop and thus skeletogenesis.
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Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis
Marcelo A. Christoffolete,Camila da Cruz Gouveia Linardi,Lucia A. de Jesus,Kátia N. Ebina,Suzy D. Carvalho,Miriam O. Ribeiro,Rogerio Rabelo,Cyntia Curcio,Luciane Martins,Edna Teruko Kimura,Antonio C. Bianco +10 more
TL;DR: The Dio2 gene encodes the type 2 deiodinase that activates thyroxine to 3,3',5-triiodothyronine, the disruption of which results in brown adipose tissue (BAT)-specific hypothyroidism in an otherwise euthyroid animal, and it is shown that reduced adrenergic responsiveness does not limit cold-induced adaptive thermogenesis.
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Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse.
Ann Marie Zavacki,Hao Ying,Marcelo A. Christoffolete,Goele Aerts,Edward So,John W. Harney,Sheue Yann Cheng,P. Reed Larsen,Antonio C. Bianco +8 more
TL;DR: The marked responsiveness of hepatic D1 to T3 relative to other genes, such as Spot14 and alpha-GPD, explains the relatively large effect of the modest increase in serum T3 in the TR alpha1(PV/+) mice, and TR alpha plays a key role in T3-dependent positive and negative regulation of the deiodinases in the cerebral cortex.