S
Sebastian van de Linde
Researcher at University of Strathclyde
Publications - 60
Citations - 7232
Sebastian van de Linde is an academic researcher from University of Strathclyde. The author has contributed to research in topics: Fluorescence-lifetime imaging microscopy & Microscopy. The author has an hindex of 31, co-authored 56 publications receiving 6465 citations. Previous affiliations of Sebastian van de Linde include University of Würzburg & Bielefeld University.
Papers
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Journal ArticleDOI
Structural analysis of herpes simplex virus by optical super-resolution imaging
Romain F. Laine,Anna Albecka,Sebastian van de Linde,Eric J. Rees,Colin M. Crump,Clemens F. Kaminski +5 more
TL;DR: Super-resolution imaging by direct stochastic optical reconstruction microscopy (dSTORM) in combination with a model-based analysis of single-molecule localization data is used, to determine the position of protein layers within virus particles and propose a model of the protein organization inside the tegument.
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Multicolor photoswitching microscopy for subdiffraction-resolution fluorescence imaging.
Sebastian van de Linde,Ulrike Endesfelder,Anindita Mukherjee,Mark Schüttpelz,Gerd Wiebusch,Steve Wolter,Mike Heilemann,Markus Sauer +7 more
TL;DR: The potential of multicolor photoswitching microscopy with subdiffraction-resolution on cytoskeletal networks and molecular quantification of proteins in the inner mitochondrial membrane with approximately 20 nm optical resolution is demonstrated.
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Correlative super-resolution fluorescence and electron microscopy of the nuclear pore complex with molecular resolution.
TL;DR: Super-resolution fluorescence localization microscopy with scanning electron microscopy is used to map the position of proteins of nuclear pore complexes in isolated Xenopus laevis oocyte nuclear envelopes with molecular resolution in both imaging modes and reveals that the nuclear pores are composed of eight gp210 (also known as NUP210) protein homodimers.
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Monitoring multiple distances within a single molecule using switchable FRET
Stephan Uphoff,Seamus Holden,Ludovic Le Reste,Javier Periz,Sebastian van de Linde,Mike Heilemann,Achillefs N. Kapanidis +6 more
TL;DR: This work introduces a method called 'switchable FRET', which combines single-molecule fluorescence resonance energy transfer (FRET) with reversible photoswitching of fluorophores, dramatically reducing the experimental and analytical complexity and enabling direct monitoring of multiple distances.
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Subdiffraction-resolution fluorescence imaging of proteins in the mitochondrial inner membrane with photoswitchable fluorophores.
TL;DR: Subdiffraction-resolution fluorescence imaging of intracellular F(0)F(1)-ATP synthase and cytochrome c oxidase in the inner membrane of mitochondria is demonstrated and it is demonstrated how quantitative data, i.e. the protein distribution in the membrane, can be derived and compared.