R
Romain F. Laine
Researcher at University College London
Publications - 70
Citations - 2186
Romain F. Laine is an academic researcher from University College London. The author has contributed to research in topics: Computer science & Fluorescence-lifetime imaging microscopy. The author has an hindex of 23, co-authored 62 publications receiving 1327 citations. Previous affiliations of Romain F. Laine include University of Cambridge & Francis Crick Institute.
Papers
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Journal ArticleDOI
Democratising deep learning for microscopy with ZeroCostDL4Mic.
Lucas von Chamier,Romain F. Laine,Romain F. Laine,Johanna Jukkala,Christoph Spahn,Daniel Krentzel,Daniel Krentzel,Elias Nehme,Martina Lerche,Sara Hernández-Pérez,Sara Hernández-Pérez,Pieta K. Mattila,Pieta K. Mattila,Eleni Karinou,Seamus Holden,Ahmet Can Solak,Alexander Krull,Tim-Oliver Buchholz,Martin L. Jones,Loic Royer,Christophe Leterrier,Yoav Shechtman,Florian Jug,Mike Heilemann,Guillaume Jacquemet,Ricardo Henriques,Ricardo Henriques,Ricardo Henriques +27 more
TL;DR: ZeroCostDL4Mic as discussed by the authors is an entry-level platform simplifying DL access by leveraging the free, cloud-based computational resources of Google Colab, which allows researchers with no coding expertise to train and apply key DL networks to perform tasks including segmentation, object detection, denoising, and image-to-image translation.
Journal ArticleDOI
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction
Janin Lautenschläger,Amberley D. Stephens,Giuliana Fusco,Giuliana Fusco,Florian Ströhl,Nathan Curry,Maria Zacharopoulou,Claire H. Michel,Romain F. Laine,Nadezhda Nespovitaya,Marcus Fantham,Dorothea Pinotsi,Dorothea Pinotsi,Wagner Zago,Paul E. Fraser,Anurag Tandon,Peter St George-Hyslop,Peter St George-Hyslop,Eric J. Rees,Jonathan J. Phillips,Alfonso De Simone,Clemens F. Kaminski,Gabriele S. Kaminski Schierle +22 more
TL;DR: This study shows that alpha-synuclein interacts with neuronal synaptic vesicles in a calcium-dependent fashion, and this interaction is important for synaptic vESicle clustering.
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RNA Docking and Local Translation Regulate Site-Specific Axon Remodeling In Vivo.
Hovy Ho-Wai Wong,Julie Qiaojin Lin,Florian Ströhl,Cláudio Gouveia Roque,Jean-Michel Cioni,Roberta Cagnetta,Benita Turner-Bridger,Romain F. Laine,William A. Harris,Clemens F. Kaminski,Christine E. Holt +10 more
TL;DR: A requirement for LPS in building arbor complexity is demonstrated and a key role for pre-synaptic LPS is suggested in assembling neural circuits.
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Structural analysis of herpes simplex virus by optical super-resolution imaging
Romain F. Laine,Anna Albecka,Sebastian van de Linde,Eric J. Rees,Colin M. Crump,Clemens F. Kaminski +5 more
TL;DR: Super-resolution imaging by direct stochastic optical reconstruction microscopy (dSTORM) in combination with a model-based analysis of single-molecule localization data is used, to determine the position of protein layers within virus particles and propose a model of the protein organization inside the tegument.
Journal ArticleDOI
TrackMate 7: integrating state-of-the-art segmentation algorithms into tracking pipelines
Dmitry Ershov,Minh Phan,Joanna W Pylvänäinen,Stéphane U Rigaud,Laure Le Blanc,Arthur Charles-Orszag,James R. W. Conway,Romain F. Laine,Nathan H. Roy,Daria Bonazzi,Guillaume Duménil,Guillaume Jacquemet,Jean-Yves Tinevez +12 more
TL;DR: TrackMate as mentioned in this paper is an automated tracking software used to analyze bioimages and is distributed as a Fiji plugin, which is built to address the broad spectrum of modern challenges researchers face by integrating state-of-the-art segmentation algorithms into tracking pipelines.