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Sébastien Vidal

Researcher at Claude Bernard University Lyon 1

Publications -  162
Citations -  5018

Sébastien Vidal is an academic researcher from Claude Bernard University Lyon 1. The author has contributed to research in topics: Glycogen phosphorylase & Lectin. The author has an hindex of 35, co-authored 159 publications receiving 4476 citations. Previous affiliations of Sébastien Vidal include University of California, Los Angeles & University of Montpellier.

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1,3-Dipolar cycloaddition reactions on carbohydrate-based templates: synthesis of spiro-isoxazolines and 1,2,4-oxadiazoles as glycogen phosphorylase inhibitors

TL;DR: In this paper, a 1,3-Dipolar cycloaddition of aryl nitrile oxides to benzyl/acetyl-protected exo -glucals and to a benzoylated glucosyl cyanide led in high yield to spiro-isoxazolines and to 3-aryl-5-glucosyl-1,2,4-oxadiazoles, respectively.
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Topological effects and binding modes operating with multivalent iminosugar-based glycoclusters and mannosidases.

TL;DR: The development of a set of tetra- and octavalent iminosugar probes with specific topologies and an assessment of their binding affinities toward a panel of glycosidases suggest that multivalency could be an alternative strategy in developing therapeutic GM inhibitors not affecting the lysosomal mannosidases.
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AFM investigation of Pseudomonas aeruginosa lectin LecA (PA-IL) filaments induced by multivalent glycoclusters.

TL;DR: Atomic force microscopy reveals that Pseudomonas aeruginosa LecA and a tetra-galactosylated 1,3-alternate calix[4]arene-based glycocluster self-assemble according to an aggregative chelate binding mode to create monodimensional filaments.