S
Sebla B. Kutluay
Researcher at Washington University in St. Louis
Publications - 38
Citations - 2019
Sebla B. Kutluay is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: RNA & Viral replication. The author has an hindex of 16, co-authored 35 publications receiving 1489 citations. Previous affiliations of Sebla B. Kutluay include Rockefeller University & Aaron Diamond AIDS Research Center.
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Journal ArticleDOI
MX2 is an interferon-induced inhibitor of HIV-1 infection
Melissa Kane,Melissa Kane,Shalini S. Yadav,Julia Bitzegeio,Julia Bitzegeio,Sebla B. Kutluay,Sebla B. Kutluay,Trinity Zang,Trinity Zang,Trinity Zang,Sam J. Wilson,John W. Schoggins,John W. Schoggins,Charles M. Rice,Masahiro Yamashita,Theodora Hatziioannou,Paul D. Bieniasz,Paul D. Bieniasz,Paul D. Bieniasz +18 more
TL;DR: Overall, these findings indicate that MX2 is an effector of the anti-HIV-1 activity of type-I IFN, and suggest thatMX2 inhibits HIV-1 infection by inhibiting capsid-dependent nuclear import of subviral complexes.
Journal ArticleDOI
Global changes in the RNA binding specificity of HIV-1 gag regulate virion genesis.
Sebla B. Kutluay,Trinity Zang,Daniel Blanco-Melo,Chelsea Powell,David Jannain,Manel Errando,Paul D. Bieniasz +6 more
TL;DR: Using crosslinking-immunoprecipitation (CLIP) sequencing, this work uncover several dramatic changes in the RNA-binding properties of Gag that occur during virion genesis, coincident with membrane binding, multimerization, and proteolytic maturation.
Journal ArticleDOI
Analysis of the initiating events in HIV-1 particle assembly and genome packaging.
TL;DR: The results suggest that HIV-1 particle assembly is initiated by the interaction between Gag and viral RNA in the cytoplasm and that this initial Gag-RNA encounter involves Gag monomers or low order multimers.
Journal ArticleDOI
Curcumin inhibits herpes simplex virus immediate-early gene expression by a mechanism independent of p300/CBP histone acetyltransferase activity
Sebla B. Kutluay,James R. Doroghazi,Martha E. Roemer,Steven J. Triezenberg,Steven J. Triezenberg +4 more
TL;DR: Results suggest that curcumin affects VP16-mediated recruitment of RNA polymerase II to IE gene promoters by a mechanism independent of p300/CBP histone acetyltransferase activity.
Journal ArticleDOI
HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis
Jacques J. Kessl,Sebla B. Kutluay,Sebla B. Kutluay,Dana Townsend,Stephanie V Rebensburg,Alison Slaughter,Ross C. Larue,Nikoloz Shkriabai,Nordine Bakouche,James R. Fuchs,Paul D. Bieniasz,Mamuka Kvaratskhelia +11 more
TL;DR: It is demonstrated that IN directly binds the viral RNA genome in virions and these interactions have specificity, as IN exhibits distinct preference for select viral RNA structural elements.