Sefan Asamitsu

TL;DR: This review addresses the recent research on synthetic G4 DNA-interacting ligands that allow targeting of selected G4s as an approach toward the discovery of highly effective anticancer drugs.

TL;DR: This review focuses on the G-quadruplex ligands that allow targeting of specific G-Quadruplexes, and unique ligands, successful methodologies, and future perspectives in relation to Specific G- quadruplex recognition are addressed.

TL;DR: This review focuses on DNA-G4 and RNA-G 4, which may have important roles in neuronal function, and reveal mechanisms underlying neurological disorders related to synaptic dysfunction, and the potential of G-quadruplexes as therapeutic targets for neurological diseases.

TL;DR: The concept of simultaneous recognition of quadruplex and its proximal duplex by hybrid molecules constructed with the dual DNA-binding components may provide a new strategy for ligand design, enabling targeting of a large variety of designated quadruplexes at specific genome locations.

TL;DR: In this article, 5-aminolevulinic acid (5-AML) was used to inhibit repeat-associated non-AUG (RAN) translation of FMRpolyG and CGG-G4RNA-induced aggregation, ameliorating aberrant synaptic plasticity and behavior in FXTAS model mice.