Zhiyong Ding

TL;DR: LKB1–AMPK pathway-dependent phosphorylation of p27 at Thr 198 stabilizes p27 and permits cells to survive growth factor withdrawal and metabolic stress through autophagy, which may contribute to tumour-cell survival under conditions of growth factor deprivation, disrupted nutrient and energy metabolism, or during stress of chemotherapy.

TL;DR: It is demonstrated that increased AXL and MET expression was associated with inferior clinical outcome in patients, and the inhibition of A XL and MET activity may overcome resistance induced by prolonged sunitinib therapy in metastatic RCC.

TL;DR: In this review, the genetic alterations of the PI3K/AKT pathway in RCC are summarized as indicated in the latest large-scale genome sequencing data, as well as treatments for RCC that target the aberrant activated PI3k/ AKT pathway.

TL;DR: It is demonstrated that AKT1 activation induces STS cell motility and invasiveness at least partially through a novel interaction with the intermediate filament vimentin (Vim), which was shown to enhance tumor and metastasis growth in vivo.

TL;DR: It is found that antiangiogenic therapy–treated RCC primary tumors showed increased infiltration of CD4+ and CD8+ T lymphocytes, which was inversely related to patient overall survival and progression-free survival, and hypotheses on resistance mechanisms to antiangIogenic therapy will guide the development of combination therapy with PD-1/PD-L1–blocking agents.