S
Sen Pathak
Researcher at University of Texas MD Anderson Cancer Center
Publications - 213
Citations - 10378
Sen Pathak is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Cancer & Cytogenetics. The author has an hindex of 48, co-authored 212 publications receiving 10008 citations. Previous affiliations of Sen Pathak include University of Virginia & University of Texas Health Science Center at Houston.
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Journal Article
Androgen-independent cancer progression and bone metastasis in the LNCaP model of human prostate cancer.
George N. Thalmann,Ploutarchos E. Anezinis,Shi Ming Chang,Haiyen E. Zhau,E. Edmund Kim,Vicki L. Hopwood,Sen Pathak,Andrew C. von Eschenbach,Leland W.K. Chung +8 more
TL;DR: It is demonstrated that one of the LNCaP sublines derived from C4-2 tumors that metastasized to the lymph node and bone acquired metastatic potential.
Journal ArticleDOI
Derivation of androgen-independent human LNCaP prostatic cancer cell sublines: Role of bone stromal cells
Hsi‐Chin ‐C Wu,Jer‐Tsong ‐T Hsieh,Martin E. Gleave,Nicholas Brown,Sen Pathak,Leland W.K. Chung +5 more
TL;DR: The results suggest that certain genetic traits of prostate cancer cells may be selected or altered through an “adaptive” mechanism that involves cellular interaction with the bone stromal cells.
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Essential role of limiting telomeres in the pathogenesis of Werner syndrome.
Sandy Chang,Asha S. Multani,Noelia G Cabrera,Maria L. Naylor,Purnima R. Laud,David B. Lombard,Sen Pathak,Leonard Guarente,Ronald A. DePinho +8 more
TL;DR: It is shown that the varied and complex cellular phenotypes of Werner syndrome are precipitated by exhaustion of telomere reserves in mice, and genetic data indicate that the delayed manifestation of the complex pleiotropic of Wrn deficiency relates to telomeres shortening.
Journal ArticleDOI
Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres.
Ling Wu,Asha S. Multani,Hua He,Wilfredo Cosme-Blanco,Yu Deng,Jian Min Deng,Olga S. Bachilo,Sen Pathak,Hidetoshi Tahara,Susan M. Bailey,Yibin Deng,Richard R. Behringer,Sandy Chang +12 more
TL;DR: It is shown that conditional deletion of Pot1a elicits a DNA damage response at telomeres, resulting in p53-dependent replicative senescence and suggests that POT1a is crucial for the maintenance of both telomere integrity and overall genomic stability.
Journal ArticleDOI
LNCaP progression model of human prostate cancer: androgen-independence and osseous metastasis.
George N. Thalmann,Robert A. Sikes,Tony T. Wu,Armelle Degeorges,Shi-Ming Chang,Mustafa Ozen,Sen Pathak,Leland W.K. Chung +7 more
TL;DR: One of the sublines, C4‐2, was found to be AI, highly tumorigenic, and metastatic, having a proclivity for metastasis to the bone.