S
Sen Wang
Researcher at Fudan University
Publications - 4
Citations - 548
Sen Wang is an academic researcher from Fudan University. The author has contributed to research in topics: Virus & Neuraminidase. The author has an hindex of 4, co-authored 4 publications receiving 490 citations. Previous affiliations of Sen Wang include Fudan University Shanghai Medical College.
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Journal ArticleDOI
Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance
Yunwen Hu,Shuihua Lu,Zhigang Song,Wei Wang,Pei Hao,Pei Hao,Jianhua Li,Xiaonan Zhang,Hui-Ling Yen,Bisheng Shi,Tao Li,Wencai Guan,Lei Xu,Yi Liu,Sen Wang,Xiaoling Zhang,Di Tian,Zhaoqin Zhu,Jing He,Kai Huang,Huijie Chen,Lulu Zheng,Xuan Li,Jie Ping,Jie Ping,Bin Kang,Xiuhong Xi,Li-jun Zha,Yixue Li,Zhiyong Zhang,Malik Peiris,Zhenghong Yuan +31 more
TL;DR: The emergence of antiviral resistance in A/H7N9 viruses, especially in patients receiving corticosteroid therapy, is concerning, needs to be closely monitored, and considered in pandemic preparedness planning.
Journal ArticleDOI
Hepatitis B Virus Surface Antigen Selectively Inhibits TLR2 Ligand–Induced IL-12 Production in Monocytes/Macrophages by Interfering with JNK Activation
Sen Wang,Zhiao Chen,Zhiao Chen,Conghua Hu,Fangxing Qian,Yuming Cheng,Min Wu,Bisheng Shi,Jieliang Chen,Yunwen Hu,Zhenghong Yuan +10 more
TL;DR: It is demonstrated that HBsAg selectively inhibits Pam3csk4- stimulated IL-12 production in M/MΦs by blocking the JNK–MAPK pathway and provide a mechanism by which HBV evades immunity and maintains its persistence.
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Polarization of Monocytic Myeloid-Derived Suppressor Cells by Hepatitis B Surface Antigen Is Mediated via ERK/IL-6/STAT3 Signaling Feedback and Restrains the Activation of T Cells in Chronic Hepatitis B Virus Infection
Zhong Fang,Jin Li,Xiaoyu Yu,Dandan Zhang,Guangxu Ren,Bisheng Shi,Cong Wang,Anna D. Kosinska,Sen Wang,Xiaohui Zhou,Maya Kozlowski,Yunwen Hu,Zhenghong Yuan +12 more
TL;DR: Hepatitis B surface Ag maintains HBV persistence and suppresses T cell responses by promoting differentiation of monocytes into mMDSCs in vitro.
Journal ArticleDOI
Drug susceptibility profile and pathogenicity of H7N9 influenza virus (Anhui1 lineage) with R292K substitution
Xiaonan Zhang,Zhigang Song,Jing He,Hui-Ling Yen,Jianhua Li,Zhaoqin Zhu,Di Tian,Wei Wang,Lei Xu,Wencai Guan,Yi Liu,Sen Wang,Bisheng Shi,Wanju Zhang,Boyin Qin,Jialin Cai,Yanmin Wan,Chunhua Xu,Xiaonan Ren,Haili Chen,Lu Liu,Yuqin Yang,Xiaohui Zhou,Wenjiang Zhou,Jianqing Xu,Xiaoyan Zhang,Malik Peiris,Yunwen Hu,Zhenghong Yuan +28 more
TL;DR: This study suggested non-NAIs should be tested clinically for H7N9 patients with a sustained high viral load and possible drug combination regimens, such as T-705 plus ribavirin, should be further tested in animal models.