There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.

Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

I and i

Probability Distributions.- Linear Models for Regression.- Linear Models for Classification.- Neural Networks.- Kernel Methods.- Sparse Kernel Machines.- Graphical Models.- Mixture Models and EM.- Approximate Inference.- Sampling Methods.- Continuous Latent Variables.- Sequential Data.- Combining Models.

Pattern Recognition and Machine Learning

CA : A Cancer Journal for Clinicians

Introduction to linear and nonlinear programming

Bilateral teleoperation: An historical survey

Most current deep learning models for hematoxylin and eosin (H&E) histopathology image analysis lack the power of generalization to datasets collected from other institutes due to the domain shift in the data. In this research, we study the domain shift problem on two prostate cancer (PCa) datasets collected from the Vancouver Prostate Centre (source dataset) and the University of Colorado (target dataset) and develop a novel center-based H&E color augmentation for cross-center model generalization. While previous work used methods such as random augmentation, color normalization, or learning domain-independent features to improve the robustness of the model to changes in H&E stains, our method first augments the H&E color space of the source dataset to color space of both datasets and then adds random color augmentation. Our method covers the larger range of the color distribution of both institutions resulting in a better generalization. We compared our method with two different State-Of-The-Art (SOTA) un-annotated domain adaptation methods: color normalization and unsupervised domain adversarial neural network (DANN) training, with an ablation study. Our proposed method improves the model performance on both the source and target datasets, and has the best performance on the unlabeled target dataset, showing promise as an approach to learning more generalizable features for histopathology image analysis.

A novel H&E color augmentation for domain invariance classification of unannotated histopathology prostate cancer images

Real-time transrectal ultrasound (TRUS) image guidance during robot-assisted laparoscopic radical prostatectomy has the potential to enhance surgery outcomes. Whether conventional or photoacoustic TRUS is used, the robotic system and the TRUS must be registered to each other. Accurate registration can be performed using photoacoustic (PA markers). However, this requires a manual search by an assistant [19]. This paper introduces the first automatic search for PA markers using a transrectal ultrasound robot. This effectively reduces the challenges associated with the da Vinci-TRUS registration. This paper investigated the performance of three search algorithms in simulation and experiment: Weighted Average (WA), Golden Section Search (GSS), and Ternary Search (TS). For validation, a surgical prostate scenario was mimicked and various ex vivo tissues were tested. As a result, the WA algorithm can achieve 0.53 degree average error after 9 data acquisitions, while the TS and GSS algorithm can achieve 0.29 degree and 0.48 degree average errors after 28 data acquisitions.

Automatic Search for Photoacoustic Marker Using Automated Transrectal Ultrasound

Transcervical Ultrasound Image Guidance System for Transoral Robotic Surgery

Abstruct- The design of a bilateral teleoperation controller is a nontrivial problem. The goal is to achieve a stable system with optimal performance in the possible presence of time delays, disturbances, uncertainties and/or measurement noise. In this paper, a general design strategy based on H, theory is presented. This approach allows a convenient means to trade off the optimization of various performance criteria and system robustness. The control approach is applied to a motion-scaling teleoperation system and simulations and experiments with the resulting controllers demonstrate that the strategy is effective.

ration Controller esign Usi with Application to Moti

In low-dose prostate brachytherapy treatment, a large number of radioactive seeds is implanted in and adjacent to the prostate gland. Planning of this treatment involves the determination of a Planning Target Volume (PTV), followed by defining the optimal number of seeds, needles and their coordinates for implantation. The two major planning tasks, i.e. PTV determination and seed definition, are associated with inter- and intra-expert variability. Moreover, since these two steps are performed in sequence, the variability is accumulated in the overall treatment plan. In this paper, we introduce a model based on a data fusion technique that enables joint determination of PTV and the minimum Prescribed Isodose (mPD) map. The model captures the correlation between different information modalities consisting of transrectal ultrasound (TRUS) volumes, PTV and isodose contours. We take advantage of joint Independent Component Analysis (jICA) as a linear decomposition technique to obtain a set of joint components that optimally describe such correlation. We perform a component stability analysis to generate a model with stable parameters that predicts the PTV and isodose contours solely based on a new patient TRUS volume. We propose a framework for both modeling and prediction processes and evaluate it on a dataset of 60 brachytherapy treatment records. We show PTV prediction error of 10:02±4:5% and the V100 isodose overlap of 97±3:55% with respect to the clinical gold standard.

Septimiu E. Salcudean

Papers

A novel H&E color augmentation for domain invariance classification of unannotated histopathology prostate cancer images

Automatic Search for Photoacoustic Marker Using Automated Transrectal Ultrasound

Transcervical Ultrasound Image Guidance System for Transoral Robotic Surgery

ration Controller esign Usi with Application to Moti

Data fusion for planning target volume and isodose prediction in prostate brachytherapy