S
Serge Jothy
Researcher at St. Michael's Hospital
Publications - 48
Citations - 3897
Serge Jothy is an academic researcher from St. Michael's Hospital. The author has contributed to research in topics: Cancer & Carcinoembryonic antigen. The author has an hindex of 24, co-authored 48 publications receiving 3790 citations. Previous affiliations of Serge Jothy include University of Toronto & McGill University.
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Journal ArticleDOI
Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule.
Sarita Benchimol,Abraham Fuks,Serge Jothy,Nicole Beauchemin,Kinji Shirota,Clifford P. Stanners +5 more
TL;DR: It is demonstrated here that CEA mediates Ca2+-independent, homotypic aggregation of cultured human colon adenocarcinoma cells (LS-180) and rodent cells transfected with functional CEA cDNA and can be considered a new addition to the family of intercellular adhesion molecules.
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The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.
Silvia M. Vidal,Michel L. Tremblay,Gregory R. Govoni,Susan A. Gauthier,Giovanna Sebastiani,Danielle Malo,Emil Skamene,Martin Olivier,Serge Jothy,Philippe Gros +9 more
TL;DR: Targeted disruption of Nramp1 has pleiotropic effects on natural resistance to infection with intracellular parasites, as it eliminated resistance to Mycobacterium bovis, Leishmania donovani, and lethal Salmonella typhimurium infection, establishing that Nramps1, Bcg, Lsh, and Ity are the same locus.
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Nef Harbors a Major Determinant of Pathogenicity for an AIDS-like Disease Induced by HIV-1 in Transgenic Mice
Zaher Hanna,Denis G. Kay,Najet Rebai,Alain Guimond,Serge Jothy,Serge Jothy,Paul Jolicoeur,Paul Jolicoeur,Paul Jolicoeur +8 more
TL;DR: The generation of Tg mice expressing selected HIV-1 gene(s) revealed that nef harbors a major disease determinant, suggesting that Nef may play a critical role in human AIDS, independently of its role in virus replication.
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Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice
Kong E. You-Ten,Eric S. Muise,Annick Itié,Eva Michaliszyn,John Wagner,Serge Jothy,Wayne S. Lapp,Michel L. Tremblay +7 more
TL;DR: It is demonstrated that hematopoietic failure in TC-PTP −/− animals was not due to a stem cell defect, but rather to a stromal cell deficiency.
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Aggressive angiomyxoma of pelvic soft parts: a clinicopathologic study of nine cases.
Louis R. Bégin,Philip B. Clement,Mary Ellen Kirk,Serge Jothy,W.T. Elliott McCaughey,Alex Ferenczy +5 more
TL;DR: Aggressive angiomyxoma should be distinguished from the more common benign and malignant myxoid neoplasms or tumor-like conditions of the pelvic soft parts and may be avoided by wide, local excision.