S
Sergei V. Kotenko
Researcher at Rutgers University
Publications - 75
Citations - 7807
Sergei V. Kotenko is an academic researcher from Rutgers University. The author has contributed to research in topics: Receptor & Interferon. The author has an hindex of 33, co-authored 70 publications receiving 7088 citations. Previous affiliations of Sergei V. Kotenko include University of Medicine and Dentistry of New Jersey & Ruhr University Bochum.
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Journal ArticleDOI
IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex.
Sergei V. Kotenko,Grant Gallagher,Vitaliy V. Baurin,Anita Lewis-Antes,Meiling Shen,Nital K. Shah,Jerome A. Langer,Faruk Sheikh,Harold Dickensheets,Raymond P. Donnelly +9 more
TL;DR: The identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state and may contribute to antiviral or other defenses by a mechanism similar to, but independent of, type I IFNs.
Journal ArticleDOI
Interferons α and λ Inhibit Hepatitis C Virus Replication With Distinct Signal Transduction and Gene Regulation Kinetics
Tobias Marcello,Arash Grakoui,Giovanna Barba-Spaeth,Erica S. Machlin,Sergei V. Kotenko,Margaret R. MacDonald,Charles M. Rice +6 more
TL;DR: Dose- and time-dependent HCV inhibition and kinetics of IFN-λ-mediated signal transducers and activators of transcription (STAT) activation and induction of potential effector genes were distinct from those ofIFN-α.
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Identification of the Functional Interleukin-22 (IL-22) Receptor Complex THE IL-10R2 CHAIN (IL-10Rβ) IS A COMMON CHAIN OF BOTH THE IL-10 AND IL-22 (IL-10-RELATED T CELL-DERIVED INDUCIBLE FACTOR, IL-TIF) RECEPTOR COMPLEXES
Sergei V. Kotenko,Lara S. Izotova,Olga V. Mirochnitchenko,Elena Esterova,Harold Dickensheets,Raymond P. Donnelly,Sidney Pestka +6 more
TL;DR: Sharing of the common IL-10R2 chain between the IL- 10 and IL-TIF receptor complexes is the first such case for receptor complexes with chains belonging to the class II cytokine receptor family, establishing a novel paradigm for IL-9-related ligands similar to the shared use of the gamma common chain by several cytokines.
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Cutting Edge: STAT Activation By IL-19, IL-20 and mda-7 Through IL-20 Receptor Complexes of Two Types
TL;DR: IL-10-related cytokines include IL-20 and IL-22, which induce, respectively, keratinocyte proliferation and acute phase production by hepatocytes, as well as IL-19, melanoma differentiation-associated gene 7, and AK155, three cytokines for which no activity nor receptor complex has been described thus far.
Journal ArticleDOI
Interferon-lambda: a new addition to an old family.
TL;DR: Ex expression of the type III IFNs (IFN-lambdas) and their primary biological activity are very similar to the type I IFNs, however, unlike IFN-alpha receptors which are broadly expressed on most cell types, including leukocytes, IFN