Sergey M. Grigoriev

TL;DR: Although Tim23p is the main structural unit of the pore Tim17p is required for twin pore structure and provides the voltage gate for the TIM23 channel, suggesting that the N terminus is vital for both voltage sensing and protein sorting.

TL;DR: Findings are consistent with the notion that MAC is the pore through which cytochrome c is released from mitochondria during apoptosis.

TL;DR: The presence of a new functional state of VDAC, a cation-selective state with conductance approximately equal to that of the canonical open state, implies that a mechanism exists for selectivity gating in VDac that is separate from partial closure, which may be relevant to the physiological regulation of this channel and mitochondrial outer membrane permeability.

TL;DR: The ability to apply electrophysiological techniques to these channels is now allowing investigations into the role of mitochondria in diverse fields such as neurotransmitter release, long-term potentiation, and apoptosis.

TL;DR: 1,2-sn-diacylglycerols (DAGs) induce Ca2+ release from Ca2-loaded mammalian mitochondria, indicating the presence of a second messenger-sensitive Ca2 + release mechanism in mitochondria that could have an important impact on intracellular Ca 2+ homeostasis.