S
Sergey Medvedev
Researcher at University of Pennsylvania
Publications - 20
Citations - 907
Sergey Medvedev is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Oocyte & RNA-binding protein. The author has an hindex of 13, co-authored 20 publications receiving 690 citations.
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Journal ArticleDOI
Absence of the DNA-/RNA-binding protein MSY2 results in male and female infertility
Juxiang Yang,Sergey Medvedev,Junying Yu,Linda C. Tang,Julio E. Agno,Martin M. Matzuk,Richard M. Schultz,Norman B. Hecht +7 more
TL;DR: Msy2 represents one of a small number of germ-cell-specific genes whose deletion leads to the disruption of both spermatogenesis and oogenesis in mice lacking Msy2.
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Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models
Hyoung Kim,Haineng Xu,Erin George,Dorothy Hallberg,Sushil Kumar,Veena Jagannathan,Sergey Medvedev,Yasuto Kinose,Kyle Devins,Priyanka Verma,Kevin Ly,Yifan Wang,Roger A. Greenberg,Lauren E. Schwartz,Neil Johnson,Robert B. Scharpf,Gordon B. Mills,Rugang Zhang,Victor E. Velculescu,Eric J. Brown,Fiona Simpkins +20 more
TL;DR: The authors show that the combination of PARP and ATR inhibitors increases the therapeutic response in PAR Pi and platinum resistant ovarium cancer PDX models, indicating that PARPi-ATRi is a highly promising strategy for OVCAs that acquire resistance to PARPi and platinum.
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The DNA/RNA-binding protein MSY2 marks specific transcripts for cytoplasmic storage in mouse male germ cells
TL;DR: It is proposed that MSY2 marks specific mRNAs in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay in meiotic and postmeiotic male germ cells of the mouse.
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Transgenic RNAi-mediated reduction of MSY2 in mouse oocytes results in reduced fertility.
TL;DR: A role for MSY2 in stabilizing maternal mRNAs in growing oocytes is supported, a process essential to generate meiotically and developmentally competent oocytes.
Journal ArticleDOI
Absence of MSY2 in Mouse Oocytes Perturbs Oocyte Growth and Maturation, RNA Stability, and the Transcriptome
TL;DR: The results strongly implicate a central role of MSY2 in regulating mRNA stability and Msy2−/− oocytes exhibit numerous phenotypes including defects in oocyte growth and maturation, RNA stability, and gene expression.