Haineng Xu

TL;DR: It is shown, in a mouse model of glioblastoma, that endothelial cells in the TME induce macrophage M2 polarization via IL-6 and that depletion of endothelial IL-8 improves survival, and it is suggested that targeting endothelialIL-6 may offer a selective and efficient therapeutic strategy for GBM, and possibly other solid malignant tumors.

TL;DR: The authors show that the combination of PARP and ATR inhibitors increases the therapeutic response in PAR Pi and platinum resistant ovarium cancer PDX models, indicating that PARPi-ATRi is a highly promising strategy for OVCAs that acquire resistance to PARPi and platinum.

TL;DR: It is found that baicalein could potently inhibit gastric cancer cell growth and colony formation and exhibited excellent tumor inhibitory effects in an in vivo subcutaneous xenograft model, indicating that baicalsein may be a potential drug for Gastric cancer therapy.

TL;DR: The authors demonstrate the role of PDGF signaling in GBM resistance to anti-VEGF treatment via a mechanism that involves endothelial-mesenchymal transformation and transcriptional regulation of VEGFR-2.

TL;DR: It is reported that GBM-derived CTC possess a cancer stem cell (CSC)-like phenotype and contribute to local tumorigenesis and recurrence by the process of self-seeding, warranting eradication of systemic "out-of-tumor" CTCs as a promising new therapeutic opportunity for GBM.