Sushil Kumar

TL;DR: Dll1cKO mice have a reduced number of MaSCs at different stages of mammary gland development in virgin and pregnant animals, and it is demonstrated that Dll1+ Ma SCs can both basal and luminal cells generate the important cellular components of the Mammary gland stem cell niche through inter-turning.

TL;DR: The authors show that the combination of PARP and ATR inhibitors increases the therapeutic response in PAR Pi and platinum resistant ovarium cancer PDX models, indicating that PARPi-ATRi is a highly promising strategy for OVCAs that acquire resistance to PARPi and platinum.

TL;DR: Findings identify a unique crosstalk between &Dgr;Np63+ TNBC cells and MDSCs that promotes tumor progression and metastasis, which could be exploited in future combined immunotherapy/chemotherapy strategies for TNBC patients.

TL;DR: The studies show that DLL1, a Notch signaling ligand, is significantly overexpressed in ERα+ luminal breast cancer, and find that estrogen signaling stabilizes D LL1 protein by preventing its proteasomal and lysososmal degradations.

TL;DR: It is shown that ELF5 loss disrupts IFNGR1 ubiquitination by FBXW7, thus enhancing IFN-γ signalling, neutrophil accumulation and PD-L1 expression to promote breast cancer progression and metastasis.