S
Sergii Afonin
Researcher at Karlsruhe Institute of Technology
Publications - 99
Citations - 3203
Sergii Afonin is an academic researcher from Karlsruhe Institute of Technology. The author has contributed to research in topics: Peptide & Lipid bilayer. The author has an hindex of 32, co-authored 93 publications receiving 2794 citations. Previous affiliations of Sergii Afonin include University of Jena.
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Journal ArticleDOI
Concentration-Dependent Realignment of the Antimicrobial Peptide PGLa in Lipid Membranes Observed by Solid-State 19F-NMR
Ralf W. Glaser,Carsten Sachse,Ulrich H.N. Dürr,Parvesh Wadhwani,Sergii Afonin,Erik Strandberg,Anne S. Ulrich +6 more
TL;DR: The membrane-disruptive antimicrobial peptide PGLa is found to change its orientation in a dimyristoyl-phosphatidylcholine bilayer when its concentration is increased to biologically active levels.
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Controlling Biological Activity with Light: Diarylethene-Containing Cyclic Peptidomimetics†
Oleg Babii,Sergii Afonin,Marina Berditsch,Sabine Reiβer,Pavel K. Mykhailiuk,Vladimir Kubyshkin,Thomas Steinbrecher,Anne S. Ulrich,Igor V. Komarov +8 more
TL;DR: A system is presented in which the polypeptide backbone itself can be conformationally switched by light and the biological activity of the resulting peptidomimetics could be effectively controlled by ultraviolet/visible light within strictly defined spatial and temporal limits.
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4‐Fluorophenylglycine as a Label for 19F NMR Structure Analysis of Membrane‐Associated Peptides
Sergii Afonin,Ralf W. Glaser,Marina Berditchevskaia,Parvesh Wadhwani,Karl-Heinz Gührs,Ute Möllmann,Andrea Perner,Anne S. Ulrich +7 more
TL;DR: The non‐natural amino acid 4‐fluorophenylglycine (4F‐Phg) was incorporated into several representative membrane‐associated peptides for dual purpose and its fusion activities suggest that the peptide is less structured in the fusogenic transition state than in the helical ground state.
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Conformation and Membrane Orientation of Amphiphilic Helical Peptides by Oriented Circular Dichroism
Jochen Bürck,Siegmar Roth,Parvesh Wadhwani,Sergii Afonin,Nathalie Kanithasen,Erik Strandberg,Anne S. Ulrich +6 more
TL;DR: Changes in peptide conformation and membrane alignment observed here by OCD seem to be functionally relevant, as they can be correlated with the membrane perturbing activities of the three antimicrobial and cell-penetrating sequences.
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Synthesis of Trifluoromethyl-Substituted Proline Analogues as 19F NMR Labels for Peptides in the Polyproline II Conformation†
Pavel K. Mykhailiuk,Pavel K. Mykhailiuk,Pavel K. Mykhailiuk,Sergii Afonin,G. V. Palamarchuk,Oleg V. Shishkin,Anne S. Ulrich,Igor V. Komarov,Igor V. Komarov +8 more