Sergii Afonin

TL;DR: The data suggest that cell uptake of amphipathic CPPs correlates with their adopted α-helix content in membranes rather than their helicity in solution, and that lactam stapling was found to vary strongly with regard to the different aspects of peptide-membrane interactions.

TL;DR: A dissociation of the anticancer activity from hemolysis was found and high PTIs were demonstrated across a range of different cancer cell lines, including a doxorubicin-resistant one.

TL;DR: Functional assays showed that the aggregation propensity of KIGAKI does not play a role in its antimicrobial action, but an increased tendency to aggregate promotes other undesirable effects such as hemolysis and membrane fusion.

TL;DR: The successful treatment of persistently infected root canals of two volunteers confirms the high effectiveness of the cyclic antimicrobial peptide gramicidin S, and suggests its applications for approval in root canal medication.

TL;DR: The structure and dynamics of the short multifunctional peptide BP100 are explored using a multinuclear solid-state NMR approach and similarity suggests that BP100 has the same surface-bound helical structure and high mobility in the different biomembranes and model membranes alike, independent of charge, thickness or cholesterol content of the system.