S
Sergii Afonin
Researcher at Karlsruhe Institute of Technology
Publications - 99
Citations - 3203
Sergii Afonin is an academic researcher from Karlsruhe Institute of Technology. The author has contributed to research in topics: Peptide & Lipid bilayer. The author has an hindex of 32, co-authored 93 publications receiving 2794 citations. Previous affiliations of Sergii Afonin include University of Jena.
Papers
More filters
Journal ArticleDOI
Orientation and Location of the Cyclotide Kalata B1 in Lipid Bilayers Revealed by Solid-State NMR
Stephan L. Grage,Marc-Antoine Sani,Olivier Cheneval,Sónia Troeira Henriques,Constantin Schalck,Ralf Heinzmann,Joshua S. Mylne,Pavel K. Mykhailiuk,Pavel K. Mykhailiuk,Sergii Afonin,Igor V. Komarov,Frances Separovic,David J. Craik,Anne S. Ulrich +13 more
TL;DR: The peptide orientation, as determined by NMR, showed that this amphipathic structure matches the polar/apolar interface of the lipid bilayer very well, and a location in the amphiphilic headgroup region of the bilayer was confirmed using solid-state 31P- and 2H-NMR.
Journal ArticleDOI
Design and Synthesis of a Monofluoro‐Substituted Aromatic Amino Acid as a Conformationally Restricted 19F NMR Label for Membrane‐Bound Peptides
Anton N. Tkachenko,Pavel K. Mykhailiuk,Pavel K. Mykhailiuk,Dmytro S. Radchenko,Dmytro S. Radchenko,Oleg Babii,Sergii Afonin,Anne S. Ulrich,Igor V. Komarov +8 more
TL;DR: According to circular dichroism analysis and molecular modeling, the 19F-labeled analogues of the known helix-inducing amino acid (1-aminocyclobutane-1-carboxylic acid) do not disrupt the peptide conformation when substituted for Phe, neither in a β-turn nor in an α-helix.
Journal ArticleDOI
Real-Time Observation of Diarylethene-Based Photoswitches in a Cyclic Peptide Environment
Caroline Schweigert,Oleg Babii,Sergii Afonin,Tim Schober,Julia Leier,Nadine C. Michenfelder,Igor V. Komarov,Anne S. Ulrich,Andreas-Neil Unterreiner +8 more
Journal ArticleDOI
Antimicrobial peptide gramicidin S is accumulated in granules of producer cells for storage of bacterial phosphagens.
Marina Berditsch,Mareike Trapp,Sergii Afonin,Christian Weber,Julia Misiewicz,Joana Turkson,Anne S. Ulrich +6 more
TL;DR: A comprehensive view on the biosynthesis of gramicidin S (GS) in Aneurinibacillus migulanus is presented, having observed a peripheral membrane localization of its synthetases.
Journal ArticleDOI
Does a methionine-to-norleucine substitution in PGLa influence peptide-membrane interactions?
Dmytro S. Radchenko,Dmytro S. Radchenko,Saskia Kattge,Sezgin Kara,Anne S. Ulrich,Sergii Afonin +5 more
TL;DR: Overall, these results confirm the functional isosterism of Nle and Met in the helical membrane-active peptides but highlight differences in the ways in which the two residues affect non-specific binding to the lipid bilayer and homomeric peptide-peptide interactions.