S
Sergio Sosa-Estani
Researcher at National Scientific and Technical Research Council
Publications - 74
Citations - 3278
Sergio Sosa-Estani is an academic researcher from National Scientific and Technical Research Council. The author has contributed to research in topics: Chagas disease & Benznidazole. The author has an hindex of 29, co-authored 70 publications receiving 2717 citations.
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Journal ArticleDOI
Benznidazole and Posaconazole in Eliminating Parasites in Asymptomatic T. Cruzi Carriers: The STOP-CHAGAS Trial
Carlos A. Morillo,Hetty Waskin,Sergio Sosa-Estani,Maria del Carmen Bangher,Carlos Cuneo,Rodolfo Milesi,Marcelo Mallagray,Werner Apt,Juan Beloscar,Joaquim Gascon,Israel Molina,Luis E. Echeverría,Hugo Colombo,José A. Pérez-Molina,Fernando Wyss,Brandi Meeks,Laura R. Bonilla,Peggy Gao,Bo Wei,Michael P. McCarthy,Salim Yusuf,Stop-Chagas Investigators +21 more
TL;DR: Posaconazole demonstrated trypanostatic activity during treatment, but it is ineffective long-term in asymptomatic T. cruzi carriers, and benznidazole monotherapy is superior to posaconazoles, with high RT-PCR conversion rates sustained at 1 year.
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Frequency of the congenital transmission of Trypanosoma cruzi: a systematic review and meta-analysis.
TL;DR: Chagas disease is caused by the parasite Trypanosoma cruzi and is endemic in much of Latin America and with increased globalisation and immigration, it is a risk in any country, partly through congenital transmission.
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Rationale and design of a randomized placebo-controlled trial assessing the effects of etiologic treatment in Chagas' cardiomyopathy: The BENznidazole Evaluation For Interrupting Trypanosomiasis (BENEFIT)
José Antonio Marin-Neto,Anis Rassi,Carlos A. Morillo,Alvaro Avezum,Stuart J. Connolly,Sergio Sosa-Estani,Fernando Rosas,Salim Yusuf +7 more
TL;DR: This is the largest trial yet conducted in Chagas' disease and will clarify the role of trypanocidal therapy in preventing cardiac disease progression and death.
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Congenital chagas disease: Recommendations for diagnosis, treatment and control of newborns, siblings and pregnant women
Yves Carlier,Faustino Torrico,Sergio Sosa-Estani,Graciela Russomando,Alejandro O. Luquetti,Héctor Freilij,Pedro Albajar Viñas +6 more
TL;DR: This article summarizes the recommendations of the Technical Group IVa on “Prevention and Control ofCongenital Transmission and Case Management of Congenital Infections” of the World Health Organization's Programme on Control of Chagas disease (infection with Trypanosoma cruzi).
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Analytical Validation of Quantitative Real-Time PCR Methods for Quantification of Trypanosoma cruzi DNA in Blood Samples from Chagas Disease Patients
Juan Carlos Ramirez,Carolina Cura,Otacilio C. Moreira,Eliane Lages-Silva,Natalia Anahí Juiz,Elsa F. Velazquez,Juan David Ramírez,Anahí Alberti,Paula Pavia,María Flores-Chávez,Arturo Muñoz-Calderón,Deyanira Pérez-Morales,José Santalla,Paulo Marcos da Matta Guedes,Julie Peneau,Paula L. Marcet,Carlos Padilla,David Cruz-Robles,Edward Valencia,Gladys Crisante,Gonzalo Greif,Inés Zulantay,Jaime A. Costales,Miriam Alvarez-Martínez,Norma Edith Martínez,Rodrigo Villarroel,Sandro Villarroel,Zunilda Sánchez,Margarita Bisio,Rudy Parrado,Lúcia Maria da Cunha Galvão,Antônia Cláudia Jácome da Câmara,Bertha Espinoza,Belkisyolé Alarcón de Noya,Concepción J. Puerta,Adelina Riarte,Patricio Diosque,Sergio Sosa-Estani,Felipe Guhl,Isabela Ribeiro,Christine Aznar,Constança Britto,Zaida E. Yadon,Alejandro G. Schijman +43 more
TL;DR: An international study to assess the performance of duplex quantitative real-time PCR (qPCR) strategies on the basis of TaqMan probes for detection and quantification of parasitic loads in peripheral blood samples from Chagas disease patients revealed a high concordance in terms of sensitivity and parasitic loads determined by both SatDNA and kDNA qPCRs.