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Seungpyo Hong
Researcher at University of Wisconsin-Madison
Publications - 172
Citations - 16299
Seungpyo Hong is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Dendrimer & Circulating tumor cell. The author has an hindex of 40, co-authored 157 publications receiving 14345 citations. Previous affiliations of Seungpyo Hong include University of Illinois at Chicago & Hodges University.
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Journal ArticleDOI
Nanocarriers as an emerging platform for cancer therapy
Dan Peer,Jeffrey M. Karp,Jeffrey M. Karp,Seungpyo Hong,Omid C. Farokhzad,Rimona Margalit,Robert Langer +6 more
TL;DR: The arsenal of nanocarriers and molecules available for selective tumour targeting, and the challenges in cancer treatment are detailed and emphasized.
Journal ArticleDOI
Interaction of polycationic polymers with supported lipid bilayers and cells: nanoscale hole formation and enhanced membrane permeability.
Seungpyo Hong,Pascale R. Leroueil,Elizabeth K. Janus,Jennifer L. Peters,Mary Margaret Kober,Mohammad T. Islam,Bradford G. Orr,James R. Baker,Mark M. Banaszak Holl +8 more
TL;DR: Data from AFM studies are consistent with the hypothesis that polycationic polymers induce the formation of transient, nanoscale holes in living cells and that these holes allow a greatly enhanced exchange of materials across the cell membrane.
Journal ArticleDOI
Interaction of poly(amidoamine) dendrimers with supported lipid bilayers and cells: hole formation and the relation to transport.
Seungpyo Hong,Anna U. Bielinska,Almut Mecke,Balazs Keszler,James L. Beals,Xiangyang Shi,Lajos P. Balogh,Bradford G. Orr,James R. Baker,Mark M. Banaszak Holl +9 more
TL;DR: A hole formation mechanism is consistent with the observations of dendrimer internalization, cytosolic proteins can diffuse out of the cell via these holes, and dye molecules can be detected diffusing into the cell or out ofThe cell through the same membrane holes.
Journal ArticleDOI
The Binding Avidity of a Nanoparticle-Based Multivalent Targeted Drug Delivery Platform
Seungpyo Hong,Pascale R. Leroueil,Istvan J. Majoros,Bradford G. Orr,James R. Baker,Mark M. Banaszak Holl +5 more
TL;DR: Data support the hypothesis that multivalent enhancement of K(D), not an enhanced rate of endocytosis, is the key factor resulting in the improved biological targeting by these drug delivery platforms.
Journal ArticleDOI
A biodegradable and biocompatible gecko-inspired tissue adhesive
Alborz Mahdavi,Lino Ferreira,Lino Ferreira,Cathryn A. Sundback,Jason W. Nichol,Edwin P. Chan,David Carter,Christopher J. Bettinger,Siamrut Patanavanich,Loice Chignozha,Eli Ben-Joseph,Alex Galakatos,Howard I. Pryor,Irina Pomerantseva,Peter T. Masiakos,William C. Faquin,Andreas Zumbuehl,Seungpyo Hong,Jeffrey T. Borenstein,Joseph P. Vacanti,Robert Langer,Jeffrey M. Karp,Jeffrey M. Karp +22 more
TL;DR: This work has created a gecko-inspired tissue adhesive from a biocompatible and biodegradable elastomer combined with a thin tissue-reactive biOCompatible surface coating that significantly increased the interfacial adhesion strength on porcine intestine tissue in vitro and in the rat abdominal subfascial in vivo environment.